1. Metabolic Enzyme/Protease
  2. MMP
  3. MMP-9-IN-1

MMP-9-IN-1 

Cat. No.: HY-135232 Purity: 99.74%
Handling Instructions

MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor, which selectively target the hemopexin (PEX) domain of MMP-9, but not other MMPs.

For research use only. We do not sell to patients.

MMP-9-IN-1 Chemical Structure

MMP-9-IN-1 Chemical Structure

CAS No. : 502887-71-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 284 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor, which selectively target the hemopexin (PEX) domain of MMP-9, but not other MMPs[1].

IC50 & Target[1]

MMP-9

 

In Vitro

MMP-9-IN-1 (compound 2; 100 μM; 14 hours) does not cause notable cytotoxicity[1].
MMP-9-IN-1 (compound 2; 10 μM) significantly inhibits cell proliferation of HT-1080 and MDA-MB-435 cells[1].

Cell Cytotoxicity Assay[1]

Cell Line: COS-1 monkey epithelial cell lines
Concentration: 100 μM
Incubation Time: 24 hours
Result: Treatment did not cause notable cytotoxicity.

Cell Proliferation Assay[1]

Cell Line: HT-1080 and MDA-MB-435 cancer cells expressing endogenous MMP-9
Concentration: 10 μM
Incubation Time: 9 days
Result: Significant inhibition of cell proliferation.
In Vivo

MMP-9-IN-1 (compound 2; 20 mg/kg; intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks) results in a profound delay in tumor growth in NCR-Nu mice bearing MDA-MB-435/GFP tumor[1].
MMP-9-IN-1 inhibits cancer cell metastasis in vivo[1].

Animal Model: 4-5 week-old female NCR-Nu mice bearing MDA-MB-435/GFP tumor[1]
Dosage: 20 mg/kg
Administration: Intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks,
Result: Resulted in a profound delay in tumor growth.
Inhibited cancer cell metastasis.
Molecular Weight

369.39

Formula

C₁₆H₁₇F₂N₃O₃S

CAS No.

502887-71-0

SMILES

O=C(NC1=CC=C(OC(F)F)C=C1)CSC2=NC(CCC)=CC(N2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (338.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7072 mL 13.5358 mL 27.0717 mL
5 mM 0.5414 mL 2.7072 mL 5.4143 mL
10 mM 0.2707 mL 1.3536 mL 2.7072 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    50% PBS

    Solubility: 5 mg/mL (13.54 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.63 mM); Clear solution

  • 3.

    Add each solvent one by one:  PBS

    Solubility: 6.67 mg/mL (18.06 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

MMP-9-IN-1MMPMatrix metalloproteinasesanti-metastaticcancerMDA-MB-435tumorlungmetastasishemopexinPEXMMP-9Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
MMP-9-IN-1
Cat. No.:
HY-135232
Quantity:
MCE Japan Authorized Agent: