2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. PDE1-IN-2

PDE1-IN-2 

Cat. No.: HY-101490 Purity: ≥98.0%
COA Handling Instructions

PDE1-IN-2 is a PDE1 inhibitor extracted from patent WO2016/55618 A1, example 31. PDE1-IN-2 has IC50 values of 6 nM, 140 nM and 164 nM for PDE1C, PDE1B and PDE1A, respectvely. PDE1-IN-2 is developed for the research of neurodegenerative disorders and psychiatric disorders.

For research use only. We do not sell to patients.

PDE1-IN-2 Chemical Structure

PDE1-IN-2 Chemical Structure

CAS No. : 1904611-63-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 352 In-stock
Solution
10 mM * 1 mL in DMSO USD 352 In-stock
Solid
1 mg USD 180 In-stock
5 mg USD 420 In-stock
10 mg USD 600 In-stock
50 mg USD 1800 In-stock
100 mg USD 2520 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

PDE1-IN-2 Related Antibodies

Top Publications Citing Use of Products

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Description

PDE1-IN-2 is a PDE1 inhibitor extracted from patent WO2016/55618 A1, example 31. PDE1-IN-2 has IC50 values of 6 nM, 140 nM and 164 nM for PDE1C, PDE1B and PDE1A, respectvely. PDE1-IN-2 is developed for the research of neurodegenerative disorders and psychiatric disorders[1].

IC50 & Target[1]

PDE1A

164 nM (IC50)

PDE1B

140 nM (IC50)

PDE1C

6 nM (IC50)

In Vitro

PDE1 enzymes are expressed in the central nervous system (CNS), making this gene family an attractive source of new targets for the treatment of psychiatric and neurodegenerative disorders[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PDE1-IN-2 Related Antibodies
Molecular Weight

381.27

Appearance

Solid

Formula

C16H21BrN4O2
CAS No.
SMILES

O=C1C2=NN=C(C3CCOCC3)N2C=C(Br)N1CC4CCCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (65.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6228 mL 13.1141 mL 26.2281 mL
5 mM 0.5246 mL 2.6228 mL 5.2456 mL
10 mM 0.2623 mL 1.3114 mL 2.6228 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (6.56 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (254 KB) HNMR (191 KB) LCMS (369 KB)

Handling Instructions (2659 KB)
References
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PDE1-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PDE1-IN-21904611-63-7Phosphodiesterase (PDE)neurodegenerativedisorderspsychiatricAlzheimer'sParkinson'sHuntington's diseasesattentiondeficithyperactivitydisorderADHDrestlesslegsyndromedepressionnarcolepsycognitiveimpairmentassociatedwithschizophreniaCIASInhibitorinhibitorinhibit

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