2. Cell Cycle/DNA Damage
  3. p97
  4. NSC804515

NSC804515 is an inhibitor of wild-type and R155H mutant p97/VCP ATPase, with an IC50 of about 15 nM for both targets. NSC804515 acts as an antiproliferative agent, disrupts the function of the ubiquitin-proteasome system, induces UbG76V-GFP accumulation, and shows reduced inhibitory potency against p97 variants carrying P510S, K512N, N616F and F618S mutations. NSC804515 can be used in research related to cancer, inclusion body myopathy with early-onset Paget's disease and frontotemporal dementia, as well as familial amyotrophic lateral sclerosis.

For research use only. We do not sell to patients.

NSC804515

NSC804515 Chemical Structure

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NSC804515 Related Antibodies

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Description

NSC804515 is an inhibitor of wild-type and R155H mutant p97/VCP ATPase, with an IC50 of about 15 nM for both targets. NSC804515 acts as an antiproliferative agent, disrupts the function of the ubiquitin-proteasome system, induces UbG76V-GFP accumulation, and shows reduced inhibitory potency against p97 variants carrying P510S, K512N, N616F and F618S mutations. NSC804515 can be used in research related to cancer, inclusion body myopathy with early-onset Paget's disease and frontotemporal dementia, as well as familial amyotrophic lateral sclerosis[1].

In Vitro

NSC804515 exhibits drastically reduced inhibitory potency against purified human p97 resistance mutants p97P510S, p97N616F, and p97F618S (over 30-fold higher IC50) and p97K512N (12-fold higher IC50) compared to wild-type p97[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NSC804515 Related Antibodies
Molecular Weight

509.57

Formula

C26H25F2N5O2S
SMILES

FC1=CC(OCC2=NN=C(S[C@H]3C=CCCC3)N2C4=CN=CC=C4)=C(F)C=C1C#CCNC(CC)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NSC804515 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC804515NSC 804515NSC-804515p97VCPCdc48p97R155HR155H mutant human p97/VCP ATPasecancerUbG76V-GFPp97WTinclusion body myopathy with early-onset paget disease and frontotemporal dementiafamilial amyotrophic lateral sclerosisubiquitin-proteasome systemhuman p97/VCP ATPaseD1-D2 domain interfaceInhibitorinhibitorinhibit

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