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NSC804515

NSC804515 is an inhibitor of wild-type and R155H mutant p97/VCP ATPase, with an IC50 of about 15 nM for both targets. NSC804515 acts as an antiproliferative agent, disrupts the function of the ubiquitin-proteasome system, induces UbG76V-GFP accumulation, and shows reduced inhibitory potency against p97 variants carrying P510S, K512N, N616F and F618S mutations. NSC804515 can be used in research related to cancer, inclusion body myopathy with early-onset Paget's disease and frontotemporal dementia, as well as familial amyotrophic lateral sclerosis.

For research use only. We do not sell to patients.

  • Formula: C26H25F2N5O2S
  • Molecular Weight:509.57
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • NSC804515 Chemical Structure
    NSC804515 Chemical Structure
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • NSC804515 Chemical Structure
    NSC804515 Chemical Structure
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  • NSC804515