2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. Somatostatin Receptor MMP
  4. Sucrose octasulfate sodium

Sucrose octasulfate sodium, a derivative of sulfated oligosaccharides, is a matrix metalloproteinase (MMP) inhibitor. Sucrose octasulfate sodium stimulates the release of somatostatin-like immunoreactivity (SLI) from the stomach by acting directly on D cells in the gastric mucosa. Sucrose octasulfate sodium exerts its ulcer-healing effect by releasing endogenous gastric somatostatin. Sucrose octasulfate sodium can be used as a pharmaceutical excipient and significantly improves wound closure in diabetic foot ulcers caused by nerve ischemia and venous leg ulcers. Sucrose octasulfate sodium can be used in the study of chronic wound healing.

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Sucrose octasulfate sodium

Sucrose octasulfate sodium Chemical Structure

CAS No. : 74135-10-7

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Based on 1 publication(s) in Google Scholar

Other Forms of Sucrose octasulfate sodium:

Sucrose octasulfate sodium Related Antibodies

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Description

Sucrose octasulfate sodium, a derivative of sulfated oligosaccharides, is a matrix metalloproteinase (MMP) inhibitor. Sucrose octasulfate sodium stimulates the release of somatostatin-like immunoreactivity (SLI) from the stomach by acting directly on D cells in the gastric mucosa. Sucrose octasulfate sodium exerts its ulcer-healing effect by releasing endogenous gastric somatostatin. Sucrose octasulfate sodium can be used as a pharmaceutical excipient and significantly improves wound closure in diabetic foot ulcers caused by nerve ischemia and venous leg ulcers. Sucrose octasulfate sodium can be used in the study of chronic wound healing[1][2][3].

In Vitro

Sucrose octasulfate (2.5-20 mg/mL; 2 h) sodium dose-dependently stimulates somatostatin-like immunoreactivity release from isolated canine gastric fundic D-cells, potentiating epinephrine-induced release at 10 and 20 mg/mL but only adding to gastrin heptadecapeptide-induced release[3].
Sucrose octasulfate (2.5-20 mg/mL; 2 h) sodium potentiates dibutyryl cyclic adenosine 3',5'-monophosphate-induced somatostatin-like immunoreactivity release from isolated canine gastric fundic D-cells, but does not potentiate 12-O-tetradecanoylphorbol 13-acetate-induced release[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sucrose octasulfate sodium Related Antibodies
Molecular Weight

1158.66

Formula

C12H14Na8O35S8
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=[S](OC[C@]([C@H]([C@@H]1O[S](=O)(O[Na])=O)O[S](=O)(O[Na])=O)(O[C@@H]1CO[S](=O)(O[Na])=O)O[C@@H](O[C@@H]2CO[S](=O)(O[Na])=O)[C@@H]([C@H]([C@@H]2O[S](=O)(O[Na])=O)O[S](=O)(O[Na])=O)O[S](=O)(O[Na])=O)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 116.67 mg/mL (100.69 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8631 mL 4.3153 mL 8.6307 mL
5 mM 0.1726 mL 0.8631 mL 1.7261 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8631 mL 4.3153 mL 8.6307 mL 21.5766 mL
5 mM 0.1726 mL 0.8631 mL 1.7261 mL 4.3153 mL
10 mM 0.0863 mL 0.4315 mL 0.8631 mL 2.1577 mL
15 mM 0.0575 mL 0.2877 mL 0.5754 mL 1.4384 mL
20 mM 0.0432 mL 0.2158 mL 0.4315 mL 1.0788 mL
25 mM 0.0345 mL 0.1726 mL 0.3452 mL 0.8631 mL
30 mM 0.0288 mL 0.1438 mL 0.2877 mL 0.7192 mL
40 mM 0.0216 mL 0.1079 mL 0.2158 mL 0.5394 mL
50 mM 0.0173 mL 0.0863 mL 0.1726 mL 0.4315 mL
60 mM 0.0144 mL 0.0719 mL 0.1438 mL 0.3596 mL
80 mM 0.0108 mL 0.0539 mL 0.1079 mL 0.2697 mL
100 mM 0.0086 mL 0.0432 mL 0.0863 mL 0.2158 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sucrose octasulfate sodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sucrose octasulfate74135-10-7Somatostatin ReceptorMMPSSTRsSSTRMatrix metalloproteinasescanine fundic D-cellsperfused rat stomachsomatostatin-like immunoreactivitymatrix metalloproteinaseepinephrinedibutyryl cyclic adenosine 3',5'-monophosphategrowth factorscanine parietal cellextracellular matrix componentsneuroischaemic diabetic foot ulcersInhibitorinhibitorinhibit

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