Sucrose octasulfate 

Sucrose octasulfate, a derivative of sulfated oligosaccharides, is a matrix metalloproteinase (MMP) inhibitor. Sucrose octasulfate stimulates the release of somatostatin-like immunoreactivity (SLI) from the stomach by acting directly on D cells in the gastric mucosa. Sucrose octasulfate exerts its ulcer-healing effect by releasing endogenous gastric somatostatin. Sucrose octasulfate can be used as a pharmaceutical excipient and significantly improves wound closure in diabetic foot ulcers caused by nerve ischemia and venous leg ulcers. Sucrose octasulfate can be used in the study of chronic wound healing^[1][2][3].

Sucrose octasulfate (2.5-20 mg/mL; 2 h) dose-dependently stimulates somatostatin-like immunoreactivity release from isolated canine gastric fundic D-cells, potentiating epinephrine-induced release at 10 and 20 mg/mL but only adding to gastrin heptadecapeptide-induced release^[3].
Sucrose octasulfate (2.5-20 mg/mL; 2 h) potentiates dibutyryl cyclic adenosine 3',5'-monophosphate-induced somatostatin-like immunoreactivity release from isolated canine gastric fundic D-cells, but does not potentiate 12-O-tetradecanoylphorbol 13-acetate-induced release^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

982.80

C₁₂H₂₂O₃₅S₈

57680-56-5

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Edmonds M, et al. Sucrose octasulfate dressing versus control dressing in patients with neuroischaemic diabetic foot ulcers (Explorer): an international, multicentre, double-blind, randomised, controlled trial. Lancet Diabetes Endocrinol. 2018 Mar;6(3):186-196.  [Content Brief]

  [2]. Dissemond J, et al. Sucrose Octasulfat – Evidenz in der Behandlung chronischer Wunden [Sucrose octasulfate-evidence in the treatment of chronic wounds]. Hautarzt. 2020 Oct;71(10):791-801. German.  [Content Brief]

  [3]. Lucey MR, et al. Sucrose octasulfate stimulates gastric somatostatin release. Am J Med. 1991 Aug 8;91(2A):52S-57S.  [Content Brief]