1. Metabolic Enzyme/Protease
  2. MMP
  3. ARP-100

ARP-100 

Cat. No.: HY-103444 Purity: >99.0%
Handling Instructions

ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1' pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM).

For research use only. We do not sell to patients.

ARP-100 Chemical Structure

ARP-100 Chemical Structure

CAS No. : 704888-90-4

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Description

ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1' pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM)[1][2].

IC50 & Target[1]

MMP-2

12 nM (IC50)

MMP-9

0.2 μM (IC50)

MMP-3

4.5 μM (IC50)

MMP-1

>50 μM (IC50)

MMP-7

>50 μM (IC50)

In Vitro

ARP-100 (50 nM) shows a significant reduction in the total number of invasive elongations[1].

Molecular Weight

364.42

Formula

C₁₇H₂₀N₂O₅S

CAS No.

704888-90-4

SMILES

O=C(NO)CN(S(=O)(C1=CC=C(C2=CC=CC=C2)C=C1)=O)OC(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

ARP-100ARP100ARP 100MMPMatrix metalloproteinasesmatrixmetalloproteinaseselectiveanti-invasivematrigelinvasionInhibitorinhibitorinhibit

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ARP-100
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