1. Metabolic Enzyme/Protease
  2. MMP
  3. PF-00356231 hydrochloride

PF-00356231 hydrochloride 

Cat. No.: HY-114091 Purity: >99.0%
Handling Instructions

PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively.

For research use only. We do not sell to patients.

PF-00356231 hydrochloride Chemical Structure

PF-00356231 hydrochloride Chemical Structure

CAS No. : 820223-77-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 481 In-stock
Estimated Time of Arrival: December 31
1 mg USD 155 In-stock
Estimated Time of Arrival: December 31
5 mg USD 470 In-stock
Estimated Time of Arrival: December 31
10 mg USD 800 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively[1].

IC50 & Target[1]

MMP-12

1.4 μM (IC50)

MMP13

0.65 nM (IC50)

MMP-3

0.39 μM (IC50)

MMP-8

1.7 μM (IC50)

MMP-9

0.98 μM (IC50)

In Vitro

PF-00356231 hydrochloride against MMP-12/13 can be affected significantly by the presence of acetohydroxamate (AH). PF-00356231 hydrochloride decreases the IC50 values of MMP-12 (0.014 μM) and MMP-13 (0.27 μM) in the presence AH[1].

Molecular Weight

464.96

Formula

C₂₅H₂₁ClN₂O₃S

CAS No.

820223-77-6

SMILES

OC(C[[email protected]](C1=CC=CC=C1)NC(C2=CC(C3=CC=C(C4=CC=NC=C4)C=C3)=CS2)=O)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

PF-00356231PF00356231PF 00356231MMPMatrix metalloproteinasesspecificnon-peptidicnon-zincchelatingligandcomplexS1pocketInhibitorinhibitorinhibit

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PF-00356231 hydrochloride
Cat. No.:
HY-114091
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