PF-00356231 hydrochloride
Based on 2 publication(s) in Google Scholar
PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 820223-77-6
- Formula: C25H21ClN2O3S
- Molecular Weight:464.96
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) PF-00356231 hydrochloride
More
Biological Activity
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MMP-12 1.4 μM (IC50) |
MMP13 0.65 nM (IC50) |
MMP-3 0.39 μM (IC50) |
MMP-8 1.7 μM (IC50) |
MMP-9 0.98 μM (IC50) |
PF-00356231 hydrochloride against MMP-12/13 can be affected significantly by the presence of acetohydroxamate (AH). PF-00356231 hydrochloride decreases the IC50 values of MMP-12 (0.014 μM) and MMP-13 (0.27 μM)? in the presence AH[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 820223-77-6
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Appearance Solid
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Molecular Weight 464.96
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Formula C25H21ClN2O3S
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Color White to light yellow
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SMILES
OC(C[C@H](C1=CC=CC=C1)NC(C2=CC(C3=CC=C(C4=CC=NC=C4)C=C3)=CS2)=O)=O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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JCI Insight
2025 Nov 24;10(22):e195743. PMID: 41277556 -
J Immunol Res
ADAM-10 Regulates MMP-12 during Lipopolysaccharide-Induced Inflammatory Response in Macrophages. [Abstract]2022 Sep 16;2022:3012218. PMID: 36157882
Solvent & Solubility
DMSO : 20.83 mg/mL (44.80 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1507 mL | 10.7536 mL | 21.5072 mL | 53.7681 mL |
| 5 mM | 0.4301 mL | 2.1507 mL | 4.3014 mL | 10.7536 mL | |
| 10 mM | 0.2151 mL | 1.0754 mL | 2.1507 mL | 5.3768 mL | |
| 15 mM | 0.1434 mL | 0.7169 mL | 1.4338 mL | 3.5845 mL | |
| 20 mM | 0.1075 mL | 0.5377 mL | 1.0754 mL | 2.6884 mL | |
| 25 mM | 0.0860 mL | 0.4301 mL | 0.8603 mL | 2.1507 mL | |
| 30 mM | 0.0717 mL | 0.3585 mL | 0.7169 mL | 1.7923 mL | |
| 40 mM | 0.0538 mL | 0.2688 mL | 0.5377 mL | 1.3442 mL |
PF-00356231 hydrochloride Related Classifications
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