PF-00356231

Cat. No.: HY-114091A: FAQs
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PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC₅₀=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC₅₀s of 0.00065, 1.7, 0.98, 0.39 μM, respectively.

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PF-00356231 Chemical Structure

CAS No. : 766536-21-4

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Other In-stock Forms of PF-00356231:

PF-00356231 hydrochloride

Other Forms of PF-00356231:

PF-00356231 hydrochloride In-stock

1 Publications Citing Use of MCE PF-00356231

•J Immunol Res. 2022 Sep 16;2022:3012218. [Abstract]

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Biological Activity
Purity & Documentation
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Description	PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC₅₀=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC₅₀s of 0.00065, 1.7, 0.98, 0.39 μM, respectively^[1].
In Vitro	PF-00356231 hydrochloride against MMP-12/13 can be affected significantly by the presence of acetohydroxamate (AH). PF-00356231 hydrochloride decreases the IC₅₀ values of MMP-12 (0.014 μM) and MMP-13 (0.27 μM)? in the presence AH^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. PF-00356231 Related Antibodies
Molecular Weight	428.50
Formula	C₂₅H₂₀N₂O₃S
CAS No.	766536-21-4
SMILES	OC(C[C@H](C1=CC=CC=C1)NC(C2=CC(C3=CC=C(C4=CC=NC=C4)C=C3)=CS2)=O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (269 KB) Handling Instructions (2659 KB)
References	[1]. Morales R, et al. Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12. J Mol Biol. 2004 Aug 20;341(4):1063-76. [Content Brief]

PF-00356231 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-00356231766536-21-4PF00356231PF 00356231MMPMatrix metalloproteinasesInhibitorinhibitorinhibit

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