Nop30 Antibody
(Synonyms: ARC, NOP, NOL3, Nucleolar protein 3, Apoptosis repressor with CARD, Muscle-enriched cytoplasmic protein, Nucleolar protein of 30 kDa, Myp, Nop30)Nop30 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Nop30.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:50-200 |
Product Details
Nop30 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Nop30.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 26 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 22 kDa
Synthetic peptide corresponding to the C-term region of human Nop30.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Nop30 may be involved in RNA splicing
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Subcellular Localization
Nucleus, nucleolus
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Expression
Tissue_Specificity: Highly expressed in heart and skeletal muscle. Detected at low levels in placenta, liver, kidney and pancreas.
Induction: Protein expression decreases in hearts failure patients and in response to oxidative stress. -
Isoforms & Post-Translational Modification
Nop30 has 3 isoforms, O60936-2: amino acid length is 208, molecular weight is 22629 Da (predicted); O60936-1: amino acid length is 219, molecular weight is 24327 Da (predicted); O60936-3: amino acid length is 270, molecular weight is 29355 Da (predicted).
Phosphorylation at Thr-149 is required for its antiapoptotic effect by blocking death-inducing signaling complex death-inducing signaling complex (DISC) activity through the control of interaction with CASP8. Phosphorylation at Thr-149 results in translocation to mitochondria and this translocation enables the binding to CASP8. Dephosphorylated at Thr-149 by calcineurin; doesn't inhibit the association between FADD and CASP8 and the consequent apoptosis. -
Subunit
Oligomerizes (via CARD doamin).
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SwissProt ID
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Synonyms
ARC, NOP, NOL3, Nucleolar protein 3, Apoptosis repressor with CARD, Muscle-enriched cytoplasmic protein, Nucleolar protein of 30 kDa, Myp, Nop30
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