NOL3 - nucleolar protein 3 Gene

Also Known as ARC; FCM; MYP; NOP; NOP30; MYOCL1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8996

About NOL3

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,170,538-67,175,737 (from NCBI)

This gene has 13 transcripts (splice variants), 89 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in skin (RPKM 15.7), prostate (RPKM 15.6) and 24 other tissues.

Summary

This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of Caspase 2, Caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

NOL3 Products (13)

mRNA	Protein	Name
NM_001185057.3	NP_001171986.1	nucleolar protein 3 isoform Nop30
NM_001276307.3	NP_001263236.1	nucleolar protein 3 isoform MYP
NM_001276309.3	NP_001263238.1	nucleolar protein 3 isoform MYP
NM_001276311.2	NP_001263240.1	nucleolar protein 3 isoform C
NM_001276312.3	NP_001263241.1	nucleolar protein 3 isoform MYP
NM_001394973.1	NP_001381902.1	nucleolar protein 3 isoform MYP
NM_001394974.1	NP_001381903.1	nucleolar protein 3 isoform C
NM_001394975.1	NP_001381904.1	nucleolar protein 3 isoform C
NM_001394976.1	NP_001381905.1	nucleolar protein 3 isoform C
NM_001394977.1	NP_001381906.1	nucleolar protein 3 isoform Nop30
NM_001394978.1	NP_001381907.1	nucleolar protein 3 isoform Nop30
NM_001394979.1	NP_001381908.1	nucleolar protein 3 isoform E
NM_003946.7	NP_003937.1	nucleolar protein 3 isoform MYP

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IMP IMP: Inferred from mutant phenotype	15509781	GOA
enables caspase binding	IPI IPI: Inferred from physical interaction	9560245	GOA
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IDA IDA: Inferred from direct assay	9560245	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10196175	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in inhibition of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	15509781	GOA
involved in mRNA splice site recognition	IDA IDA: Inferred from direct assay	10196175	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15509781	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	9560245	GOA
involved in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	15004034	GOA
involved in negative regulation of release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	15004034	GOA
involved in protein complex oligomerization	IDA IDA: Inferred from direct assay	10196175	GOA
involved in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	15509781	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10196175	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	10196175	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOL3 Protein Structure

CARD

0
100
208 a.a.

Protein Preferred Names	Protein Names
nucleolar protein 3	muscle-enriched cytoplasmic protein

NOL3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NOL3	O60936	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	NOL3	O60936	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	NOL3	O60936	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	NOL3	O60936	TINF2	Homo sapiens	Q9BSI4	Pull Down	21044950
Intra	NOL3	O60936	ETNK2	Homo sapiens	Q9NVF9	Y2H Pooling	16189514
Intra	NOL3	O60936	NOL3	Homo sapiens	O60936	Y2H Pooling	16189514
Intra	NOL3	O60936	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	NOL3	O60936	POT1	Homo sapiens	Q9NUX5	BiFC	21044950
Intra	NOL3	O60936	CASP8	Homo sapiens	Q14790	Anti Tag CoIP	18245485
Intra	NOL3	O60936	NIF3L1	Homo sapiens	Q9GZT8	Y2H Pooling	16189514
Intra	NOL3	O60936	CASP8	Homo sapiens	Q14790	Anti Bait CoIP	18245485
Intra	NOL3	O60936	NOL3	Homo sapiens	O60936	Pull Down	16189514
Intra	NOL3	O60936	SIRPA	Homo sapiens	P78324	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NOL3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7540	ARC Protein, Human	O60936 (M1-S208)	≥ 95%, as determined by reducing SDS-PAGE.

NOL3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810953	Nop30 Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P811234	Nop30/ ARC Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Myoclonus, Familial, 1	Myoclonus, Familial Cortical MYOCL1 Fcm Familial Cortical Myoclonus
Myoclonus
Ischemia	Acute Coronary Syndrome
Ulcerative Stomatitis	Stomatitis Ulcerative Aphthous Stomatitis Minor Oral Aphthous Ulceration
Familial Adult Myoclonic Epilepsy	Benign Adult Familial Myoclonus Epilepsy Bafme Benign Adult Familial Myoclonic Epilepsy Fame Familial Cortical Myoclonic Tremor And Epilepsy Fcmte Adcme Autosomal Dominant Cortical Myoclonus And Epilepsy Fam Epilepsy, Myoclonic, Familial Adult Epilepsy, Myoclonic, Benign Adult Familial, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09414	NOL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18487	Nol3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24969	Nol3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NOL3	RGD	RGD:708558
Bos taurus	NOL3	VGNC	VGNC:32156
Felis catus	NOL3	VGNC	VGNC:68512
Macaca mulatta	NOL3	VGNC	VGNC:99529
Mus musculus	NOL3	MGD	MGI:1925938
Others	NOL3	NCBI