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Cat. No.: HY-156130

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Menin-MLL inhibitor 29

Menin-MLL inhibitor 29 (Compound C1) is a Menin-MLL PPI inhibitor. Menin-MLL inhibitor 29 binds to Menin with a K_D value of 138 nM, and inhibits the binding of Menin to MBM1 (Menin-binding motif 1) with an IC₅₀ value of 46 nM. Menin-MLL inhibitor 29 inhibits HepG2 and Hep3B hepatoma cell proliferation (IC₅₀s: 0.31 μM and 0.71 μM). Menin-MLL inhibitor 29 inhibits tumor growth.

For research use only. We do not sell to patients.

Formula: C₃₆H₂₆Br₂F₆N₄PRh
Molecular Weight:922.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Menin-MLL inhibitor 29 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

IC₅₀ & Target

Menin-MLL PPI^[1]

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Chemical Information

Molecular Weight 922.30
Formula C₃₆H₂₆Br₂F₆N₄PRh
SMILES

BrC1=C[C-]([Rh+3]23([C-]4=CC(Br)=CC=C4C5=[N]2C=CC=C5)([N]6=CC=CC7=C6C8=C(C(C)=C7C)C=CC=[N]38)[N]9=C%10C=CC=C9)=C%10C=C1.[F-][P+5]([F-])([F-])([F-])([F-])[F-]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhong HJ, et al. Development of an orally bioavailable selective inhibitor of the menin-MLL. Genes Dis. 2022 Oct 18;10(5):1735-1738. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Menin-MLL inhibitor 29

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