RO-28-2653
RO-28-2653 is an orally active matrix metalloproteinase (MMP) inhibitor. RO-28-2653 exhibits highly selective inhibitory effects on MMP2, MMP9 and membrane-type 1-MMP, and may reduce side effects (such as musculoskeletal pain) compared to broad-spectrum MMP inhibitors. RO-28-2653 shows significant tumor growth inhibition in a rat prostate model. RO-28-2653 can be used in studies of hormone-sensitive tumors.
For research use only. We do not sell to patients.
- CAS No.: 261956-22-3
- Formula: C26H23N5O5
- Molecular Weight:485.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MMP-2 |
MMP-9 |
Chemical Information
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CAS No. 261956-22-3
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Molecular Weight 485.49
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Formula C26H23N5O5
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SMILES
O=C1NC(C(N2CCN(C3=CC=C([N+]([O-])=O)C=C3)CC2)(C4=CC=C(C5=CC=CC=C5)C=C4)C(N1)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Abramjuk C, et al. Matrix metalloproteinase inhibitor Ro 28-2653 in combination with estramustine: tumor-reducing effects on hormone-sensitive prostate cancer in rats. Anticancer Drugs. 2005 Sep;16(8):855-61. [Content Brief]
[2]. iette M, et al. Pharmacokinetic study of a new synthetic MMP inhibitor (Ro 28-2653) after IV and oral administration of cyclodextrin solutions. Eur J Pharm Sci. 2006 Jun;28(3):189-95. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RO-28-2653 Related Classifications
HY-109747 Related Classifications
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