261956-22-3
Chemical Structure
RO-28-2653
- CAS No.: 261956-22-3
- Formula:C26H23N5O5
- Molecular Weight:485.49
IUPAC Name: 5-([1,1'-biphenyl]-4-yl)-5-(4-(4-nitrophenyl)piperazin-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione
InChIKey: NJKTYSXXGARILV-UHFFFAOYSA-N
SMILES: O=C1NC(C(N2CCN(C3=CC=C([N+]([O-])=O)C=C3)CC2)(C4=CC=C(C5=CC=CC=C5)C=C4)C(N1)=O)=O
Biological Activity: RO-28-2653 is an orally active matrix metalloproteinase (MMP) inhibitor. RO-28-2653 exhibits highly selective inhibitory effects on MMP2, MMP9 and membrane-type 1-MMP, and may reduce side effects (such as musculoskeletal pain) compared to broad-spectrum MMP inhibitors. RO-28-2653 shows significant tumor growth inhibition in a rat prostate model. RO-28-2653 can be used in studies of hormone-sensitive tumors[1][2].
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RO-28-2653 | RO-28-2653 is an orally active matrix metalloproteinase (MMP) inhibitor. RO-28-2653 exhibits highly selective inhibitory effects on MMP2, MMP9 and membrane-type 1-MMP, and may reduce side effects (such as musculoskeletal pain) compared to broad-spectrum MMP inhibitors. RO-28-2653 shows significant tumor growth inhibition in a rat prostate model. RO-28-2653 can be used in studies of hormone-sensitive tumors. | |||||||||||||||||||||
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References
- [1]. Abramjuk C, et al. Matrix metalloproteinase inhibitor Ro 28-2653 in combination with estramustine: tumor-reducing effects on hormone-sensitive prostate cancer in rats. Anticancer Drugs. 2005 Sep;16(8):855-61. [Content Brief]
- [2]. iette M, et al. Pharmacokinetic study of a new synthetic MMP inhibitor (Ro 28-2653) after IV and oral administration of cyclodextrin solutions. Eur J Pharm Sci. 2006 Jun;28(3):189-95. [Content Brief]
