FADD Antibody (YA5328)
(Synonyms: FADD; FADD protein; FADD_HUMAN; Fas; TNFRSF6; associated via death domain; Fas associated via death domain; Fas associating death domain containing protein; Fas associating death domain containing protein; Fas associating protein; Fas associating protein with death domain; Fas associating protein with death domain; Fas TNFRSF6 associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; FasTNFRSF6 associated via death domain; FasTNFRSF6 associated via death domain; GIG 3; GIG3; Growth inhibiting gene 3 protein; Growth-inhibiting gene 3 protein; H sapiens mRNA for mediator of receptor induced toxicity; H sapiens mRNA for mediator of receptor induced toxicity; Mediator of receptor induced toxicity; Mediator of receptor induced toxicity; MGC8528; MGC8528; MORT 1; MORT1; MORT1; Protein FADD.)
Based on 1 Customer Validation
FADD Antibody (YA5328) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FADD.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
WB, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with <0.1% sodium azide and 0.1% gelatin.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:100-1:1000 | 1:50-1:500 | 1:30-1:3000 |
Product Details
FADD Antibody (YA5328) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FADD.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 27 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Purified recombinant human FADD 28-209AA.
affinity chromatography.
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with <0.1% sodium azide and 0.1% gelatin.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at 2-8°C for 1 year, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
FADD is an Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling[1][2][3][4][5][6][7][8][9].
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Subcellular Localization
Cytoplasm
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Expression
Tissue_specificity:Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes -
Subunit
Can self-associate (PubMed:19118384, PubMed:20935634).
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SwissProt ID
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Synonyms
FADD; FADD protein; FADD_HUMAN; Fas; TNFRSF6; associated via death domain; Fas associated via death domain; Fas associating death domain containing protein; Fas associating death domain containing protein; Fas associating protein; Fas associating protein with death domain; Fas associating protein with death domain; Fas TNFRSF6 associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; FasTNFRSF6 associated via death domain; FasTNFRSF6 associated via death domain; GIG 3; GIG3; Growth inhibiting gene 3 protein; Growth-inhibiting gene 3 protein; H sapiens mRNA for mediator of receptor induced toxicity; H sapiens mRNA for mediator of receptor induced toxicity; Mediator of receptor induced toxicity; Mediator of receptor induced toxicity; MGC8528; MGC8528; MORT 1; MORT1; MORT1; Protein FADD.
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