RAIDD Antibody
(Synonyms: RAIDD, CRADD, Death domain-containing protein CRADD, Caspase and RIP adapter with death domain, RIP-associated protein with a death domain)RAIDD Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to RAIDD.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
RAIDD Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to RAIDD.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 26 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 22 kDa
Synthetic peptide corresponding to the center region of human RAIDD.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RAIDD is an Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway[1][2][3][4][5][6].
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Subcellular Localization
Cytoplasm; Nucleus
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Expression
Tissue_Specificity: Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. -
Isoforms & Post-Translational Modification
RAIDD has 2 isoforms, P78560-1: amino acid length is 199, molecular weight is 22745 Da (predicted); P78560-2: amino acid length is 103, molecular weight is 11826 Da (predicted).RAIDD 存在 2 个异构体，P78560-1：氨基酸个数为 199 个，分子量为 22745 Da (预测)；P78560-2：氨基酸个数为 103 个，分子量为 11826 Da (预测)。
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Subunit
Forms a complex named the PIDDosome with PIDD1 and CASP2.
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SwissProt ID
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Synonyms
RAIDD, CRADD, Death domain-containing protein CRADD, Caspase and RIP adapter with death domain, RIP-associated protein with a death domain
Documentation
[1]. Tinel A, et al. The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science. 2004 May 7;304(5672):843-6. [Content Brief]
[2]. Vakifahmetoglu H, et al. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. Oncogene. 2006 Sep 14;25(41):5683-92. [Content Brief]
[3]. Tinel A, et al. Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway. EMBO J. 2007 Jan 10;26(1):197-208. [Content Brief]
[4]. Park HH, et al. Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell. 2007 Feb 9;128(3):533-46. [Content Brief]
[5]. Ahmad M, et al. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. Cancer Res. 1997 Feb 15;57(4):615-9. [Content Brief]
[6]. Duan H, et al. RAIDD is a new 'death' adaptor molecule. Nature. 1997 Jan 2;385(6611):86-9. [Content Brief]
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