1. Metabolic Enzyme/Protease
  2. MMP
  3. CP-544439

CP-544439 

Cat. No.: HY-107013
Handling Instructions

CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 0.75 nM.

For research use only. We do not sell to patients.

CP-544439 Chemical Structure

CP-544439 Chemical Structure

CAS No. : 230954-09-3

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Description

CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 0.75 nM[1][2].

IC50 & Target[2] [1] [1]

MMP-13

0.75 nM (IC50)

MMP-12

0.24 nM (IC50)

MMP-1

420 nM (IC50)

MMP-2

1.6 nM (IC50)

MMP-3

16 nM (IC50)

MMP-8

1.4 nM (IC50)

MMP-9

12 nM (IC50)

MMP-14

7.4 nM (IC50)

In Vivo

In vivo studies using a hamster model, in which the cartilage collagen degradation was induced by intra-articular injection of recombinant human MMP-13, demonstrated that oral administration of CP-544439 inhibits degradation of the cartilage collagen with an ED50 of 14 mg/kg and efficacious plasma concentrations ranging from 0.5 to 1.0 g/ml[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

410.42

Formula

C₁₈H₁₉FN₂O₆S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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CP-544439
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