CP-544439
CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 0.75 nM.
For research use only. We do not sell to patients.
- CAS No.: 230954-09-3
- Formula: C18H19FN2O6S
- Molecular Weight:410.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MMP-13 0.75 nM (IC50) |
MMP-12 0.24 nM (IC50) |
MMP-1 420 nM (IC50) |
MMP-2 1.6 nM (IC50) |
MMP-3 16 nM (IC50) |
MMP-8 1.4 nM (IC50) |
MMP-9 12 nM (IC50) |
MMP-14 7.4 nM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 230954-09-3
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Molecular Weight 410.42
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Formula C18H19FN2O6S
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SMILES
O=C(NO)C1(CCOCC1)NS(=O)(C2=CC=C(C=C2)OC3=CC=C(C=C3)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Dalvie D, et al. Metabolism distribution and excretion of a matrix metalloproteinase-13 inhibitor, 4-[4-(4-fluorophenoxy)-benzenesulfonylamino]tetrahydropyran-4-carboxylic acid hydroxyamide (CP-544439), in rats and dogs: assessment of the metabolic profil [Content Brief]
[2]. Reiter LA, et al. Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1. Bioorg Med Chem Lett. 2004;14(13):3389-3395. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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