230954-09-3
230954-09-3
Chemical Structure
CP-544439
- CAS No.: 230954-09-3
- Formula:C18H19FN2O6S
- Molecular Weight:410.42
IUPAC Name: 4-((4-(4-fluorophenoxy)phenyl)sulfonamido)-N-hydroxytetrahydro-2H-pyran-4-carboxamide
InChIKey: ZBRHTUMWSDPCMI-UHFFFAOYSA-N
SMILES: O=C(NO)C1(CCOCC1)NS(=O)(C2=CC=C(C=C2)OC3=CC=C(C=C3)F)=O
Biological Activity: CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 0.75 nM[1][2].
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CP-544439 | CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 0.75 nM. | |||||||||||||||||||||
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References
- [1]. Dalvie D, et al. Metabolism distribution and excretion of a matrix metalloproteinase-13 inhibitor, 4-[4-(4-fluorophenoxy)-benzenesulfonylamino]tetrahydropyran-4-carboxylic acid hydroxyamide (CP-544439), in rats and dogs: assessment of the metabolic profil [Content Brief]
- [2]. Reiter LA, et al. Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1. Bioorg Med Chem Lett. 2004;14(13):3389-3395. [Content Brief]
Keywords
