ADI-14359 

ADI-14359 is an antibody that binds to RSV postF, with a K_D value of 387 nM, and exhibits non-neutralizing activity. ADI-14359 binds to antigenic site I on RSV postF through interactions of its conserved CDR H3 motif, germline-encoded IGKV1-39 light chain residues and heavy chain residues, where the light chain mediates preferential binding to postF by conflicting with the rearranged preF region. ADI-14359 can be used in studies related to respiratory syncytial virus (RSV) infection^[1].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Human

ADI-14359 binds to epitope I of RSV postF via convergent CDR H3 motifs and germline-encoded features of its IGKV1-39 light chain and IGHV2-70 heavy chain, with key interactions mediated by specific hydrogen bonds and electrostatic contacts^[1].
ADI-14359 (6.25 nM-1600 nM) binds to RSV postF with a K_D value of 387 nM; the heavy chain Arg50 residue and postF Lys390 residue are critical for this interaction, as disruption of these residues significantly reduces or even completely abolishes binding^[1].
ADI-14359 recognizes antigenic epitope I on RSV F, preferentially binds to the post-fusion conformation, and does not neutralize RSV^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

A0A0X8XRK2

RSV-F

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Goodwin E, et al. Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation. Immunity. 2018;48(2):339-349.e5.