2. Peptides
  3. Properdistatin

Properdistatin is a peptide derived from the thrombospondin 1 (TSP-1) domain of properdin. Properdistatin inhibits angiogenesis and improves vascular function. Properdistatin has the potential for the research of melanoma.

For research use only. We do not sell to patients.

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Properdistatin Chemical Structure

Properdistatin Chemical Structure

CAS No. : 945373-85-3

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Properdistatin Related Antibodies

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Description

Properdistatin is a peptide derived from the thrombospondin 1 (TSP-1) domain of properdin. Properdistatin inhibits angiogenesis and improves vascular function. Properdistatin has the potential for the research of melanoma[1].

In Vivo

Properdistatin (80 mg/kg; i.p.; daily for 4 days) inhibits angiogenesis and improves vascular function in mouse melanoma xenograft model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult female BALB/c nu/nu mice (R-18, A-07, and D-12 human melanoma cells)[1]
Dosage: 80 mg/kg
Administration: I.p.; daily for 4 days
Result: Inhibited angiogenesis in human melanoma xenografts with low TSP-1 expression, selectively removed small-diameter capillaries, but did not change the morphology of tumor arterioles or tumor venules, and reduced blood supply times and increased plasma velocities.
Molecular Weight

2177.47

Formula

C89H149N33O27S2
CAS No.
Sequence Shortening

GPWEPCSVTCSKGTRTRRR
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Purity & Documentation
References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Properdistatin945373-85-3OthersangiogenesisTSP-1melanomaR-18A-07D-12 cellsInhibitorinhibitorinhibit

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