1. Metabolic Enzyme/Protease
  2. MMP
  3. TP0556351

TP0556351 is a potent and selective matrix metalloproteinase-2 (MMP2) inhibitor with an IC50 value of 0.2 nM. TP0556351 reduces the amount of collagen in the lungs of a Bleomycin-induced pulmonary fibrosis mouse model. TP0556351 can be used for researching idiopathic pulmonary fibrosis (IPF).

For research use only. We do not sell to patients.

TP0556351 Chemical Structure

TP0556351 Chemical Structure

CAS No. : 2787582-17-4

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Description

TP0556351 is a potent and selective matrix metalloproteinase-2 (MMP2) inhibitor with an IC50 value of 0.2 nM. TP0556351 reduces the amount of collagen in the lungs of a Bleomycin-induced pulmonary fibrosis mouse model. TP0556351 can be used for researching idiopathic pulmonary fibrosis (IPF)[1].

IC50 & Target[1]

MMP-2

0.2 nM (IC50)

In Vivo

TP0556351 (0.03, 0.1, 0.3, or 1 mg/kg/day; SC, for 14 days) reduces the amount of collagen in the lungs of a Bleomycin-induced pulmonary fibrosis mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1067.15

Formula

C50H70N10O16

CAS No.
SMILES

CC(C[C@@H](C(N([C@H](C(N1CCC[C@H]1CC(N)=O)=O)CCC(O)=O)C)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(CCCCNC(C2=CC=C(OC3=CC=C(C(N)=O)C=C3)C=C2)=O)=O)CCC(O)=O)=O)CC(O)=O)=O)CCN)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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TP0556351 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
TP0556351
Cat. No.:
HY-147936
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