2. Metabolic Enzyme/Protease Apoptosis Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt
  3. MMP Apoptosis EGFR STAT
  4. MG-3C

MG-3C is a potent matrix metalloproteinase 9 (MMP-9) inhibitor. MG-3C can selectively kill non-small-cell lung cancer (NSCLC) cells harboring the EGFR T790M mutation. MG-3C blocks the EGFR/STAT3 signaling pathway, inducing G2/M phase arrest, growth inhibition, and apoptosis of cancer cells. MG-3C is promising for research of lung cancer.

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MG-3C

MG-3C Estructura química

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MG-3C Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas MMP:

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

Ver todos los productos específicos de isoformas STAT:

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STAT3 STAT5 STAT6 STAT1

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Descripciòn

MG-3C is a potent matrix metalloproteinase 9 (MMP-9) inhibitor. MG-3C can selectively kill non-small-cell lung cancer (NSCLC) cells harboring the EGFR T790M mutation. MG-3C blocks the EGFR/STAT3 signaling pathway, inducing G2/M phase arrest, growth inhibition, and apoptosis of cancer cells. MG-3C is promising for research of lung cancer[1].

IC50 & Target

MMP-9

 

Peso molecular

660.74

Fòrmula

C36H32N6O5S
SMILES

O=C(C1=C2C(C(SC3=CC=C(/N=N\C4=CC=C(C(NCCCN5C(C=CC5=O)=O)=O)C=C4)C=C3)=CC=C26)=CC=C1)N(CCN(C)C)C6=O
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Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
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MG-3C Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MG-3CMMPApoptosisEGFRSTATMatrix metalloproteinasesEpidermal growth factor receptorErbB-1HER1MMP-9NSCLCapoptosislung cancerInhibitorinhibitorinhibit

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Nombre del producto:
MG-3C
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HY-173500
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