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CCDC98 Antibody (YA6493)

(Synonyms: 3830405G04Rik antibody; 5630400M01Rik antibody; ABRA1 antibody; ABRAXAS antibody; Abraxas protein antibody; AI506069 antibody; AL024423 antibody; AV118690 antibody; BRCA1-A complex subunit Abraxas antibody; coiled coil domain containing 98 antibody; 3830405G04Rik antibody; 5630400M01Rik antibody; ABRA1 antibody; ABRAXAS antibody; Abraxas protein antibody; AI506069 antibody; AL024423 antibody; AV118690 antibody; BRCA1-A complex subunit Abraxas antibody; coiled coil domain containing 98 antibody; Coiled-coil domain-containing protein 98 antibody; F175A_HUMAN antibody; FAM175A antibody; Family with sequence similarity 175 member A antibody; FLJ11520 antibody; FLJ12642 antibody; FLJ13614 antibody; Protein FAM175A antibody; )
Customer Review

Based on 1 Customer Validation

CCDC98 Antibody (YA6493) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CCDC98.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, ICC/IF, IHC-P, FC

  • Reactivity :

    Human

  • Formulation:

    Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for CCDC98 Antibody (YA6493)
  • CCDC98 Antibody (YA6493) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Service
Data Download
Related Products:
Top Publications Citing

Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
FC Info
FC: Flow Cytometry
Dilution Ratio 1:500-1:2000 1:50-1:100 1:100-1:500 1:50-1:100

Product Details

Description

CCDC98 Antibody (YA6493) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CCDC98.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human
  • Calculated Molecular Weight Predicted band size: 47 kDa
Immunogen

Synthetic peptide within human CCDC98 aa 360-409/409.

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for CCDC98 Antibody (YA6493)
    Western blot analysis of extracts from K562 (lane 1(20μg)) 、Daudi (lane 2(20μg)) 、HL-60 (lane 3(20μg)) and MCF7 (lane 4(20μg)) using CCDC98 Antibody (HY-P86800) . Proteins were transferred to a PVDF membrane and blocked with 5% nonfat dry milk in TBST for 1.5 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Hsp90, 1/10000) was used in 5% nonfat dry milk in TBST at 4℃ overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (1/10,000) was used for 1 hour at room temperature.

Background

  • Function

    CCDC98 is involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX

  • Subcellular Localization

    Nucleus

  • Isoforms & Post-Translational Modification

    Q6UWZ7 has two isomers: Q6UWZ7-1: 46663 Da (predicted); Q6UWZ7-2: 34447 Da (predicted).
    Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1 (PubMed:17525340, PubMed:17643121, PubMed:17643122)

  • Subunit

    Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1 (PubMed:24075985)

  • SwissProt ID

    Q6UWZ7

  • Gene ID
    84142 [NCBI]
  • Synonyms

    3830405G04Rik antibody; 5630400M01Rik antibody; ABRA1 antibody; ABRAXAS antibody; Abraxas protein antibody; AI506069 antibody; AL024423 antibody; AV118690 antibody; BRCA1-A complex subunit Abraxas antibody; coiled coil domain containing 98 antibody; 3830405G04Rik antibody; 5630400M01Rik antibody; ABRA1 antibody; ABRAXAS antibody; Abraxas protein antibody; AI506069 antibody; AL024423 antibody; AV118690 antibody; BRCA1-A complex subunit Abraxas antibody; coiled coil domain containing 98 antibody; Coiled-coil domain-containing protein 98 antibody; F175A_HUMAN antibody; FAM175A antibody; Family with sequence similarity 175 member A antibody; FLJ11520 antibody; FLJ12642 antibody; FLJ13614 antibody; Protein FAM175A antibody;

CCDC98 Antibody (YA6493) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     Western blot analysis of extracts from K562 (lane 1(20μg)) 、Daudi (lane 2(20μg)) 、HL-60 (lane 3(20μg)) and MCF7 (lane 4(20μg)) using CCDC98 Antibody (HY-P86800) . Proteins were transferred to a PVDF membrane and blocked with 5% nonfat dry milk in TBST for 1.5 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Hsp90, 1/10000) was used in 5% nonfat dry milk in TBST at 4℃ overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (1/10,000) was used for 1 hour at room temperature.

  • CCDC98 Antibody (YA6493) Product Image
    1/16
  • Experimental Validation Results for CCDC98 Antibody (YA6493)
  • CCDC98 Antibody (YA6493) Product Image
  • Experimental Validation Results for CCDC98 Antibody (YA6493)
    1/1
    MedChemExpress Validation
     Western blot analysis of extracts from K562 (lane 1(20μg)) 、Daudi (lane 2(20μg)) 、HL-60 (lane 3(20μg)) and MCF7 (lane 4(20μg)) using CCDC98 Antibody (HY-P86800) . Proteins were transferred to a PVDF membrane and blocked with 5% nonfat dry milk in TBST for 1.5 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Hsp90, 1/10000) was used in 5% nonfat dry milk in TBST at 4℃ overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (1/10,000) was used for 1 hour at room temperature.
  • Experimental Validation Results for CCDC98 Antibody (YA6493)
  • CCDC98 Antibody (YA6493) Product Image
    MedChemExpress Validation

    Western blot analysis of extracts from K562 (lane 1(20μg)) 、Daudi (lane 2(20μg)) 、HL-60 (lane 3(20μg)) and MCF7 (lane 4(20μg)) using CCDC98 Antibody (HY-P86800) . Proteins were transferred to a PVDF membrane and blocked with 5% nonfat dry milk in TBST for 1.5 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Hsp90, 1/10000) was used in 5% nonfat dry milk in TBST at 4℃ overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (1/10,000) was used for 1 hour at room temperature.

  • CCDC98 Antibody (YA6493) Product Image WB