MMP16 Antibody
(Synonyms: C8orf57, MMPX2, MMP16, Matrix metalloproteinase-16, MMP-16, MMP-X2, Membrane-type matrix metalloproteinase 3, Membrane-type-3 matrix metalloproteinase, MT-MMP 3, MTMMP3, MT3-MMP, MT3MMP)MMP16 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to MMP16.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:50-200 |
Product Details
MMP16 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to MMP16.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 62; 55 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 52; 69 kDa
Synthetic peptide corresponding to the C-term region of human MMP16.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MMP16 is an Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary. -
Isoforms & Post-Translational Modification
MMP16 has 2 isoforms, P51512-1: amino acid length is 607, molecular weight is 69521 Da (predicted); P51512-2: amino acid length is 457, molecular weight is 52515 Da (predicted).The precursor is cleaved by a furin endopeptidase
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Subunit
Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan
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SwissProt ID
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Synonyms
C8orf57, MMPX2, MMP16, Matrix metalloproteinase-16, MMP-16, MMP-X2, Membrane-type matrix metalloproteinase 3, Membrane-type-3 matrix metalloproteinase, MT-MMP 3, MTMMP3, MT3-MMP, MT3MMP
Documentation
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