MMP16 - matrix metallopeptidase 16 Gene

Also Known as MMP-X2; C8orf57; MT-MMP2; MT-MMP3; MT3-MMP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4325

About MMP16

Cytogenetic location: 8q21.3 Genomic coordinates (GRCh38): 8:88,032,011-88,327,483 (from NCBI)

This gene has 4 transcripts (splice variants), 271 orthologues and 23 paralogues. Biased expression in brain (RPKM 3.8), gall bladder (RPKM 1.9) and 12 other tissues.

Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]

MMP16 Products (1)

mRNA Protein Name
NM_005941.5 NP_005932.2 matrix metalloproteinase-16 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables metalloaminopeptidase activity IDA
IDA: Inferred from direct assay
24970228 GOA
enables metalloendopeptidase activity IDA
IDA: Inferred from direct assay
27229514 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
27229514 GOA
Biological Process GO Annotation Evidence References Source
involved in protein processing IDA
IDA: Inferred from direct assay
27229514 GOA
involved in proteolysis IDA
IDA: Inferred from direct assay
24970228 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
7559440 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MMP16 Protein Structure

PG_binding_1

PG_binding_1: Putative peptidoglycan binding domain (43 - 96)

Peptidase_M10

Peptidase_M10: Matrixin (126 - 291)

Hemopexin

Hemopexin: Hemopexin (355 - 390)

Hemopexin

Hemopexin: Hemopexin (392 - 435)

Hemopexin

Hemopexin: Hemopexin (439 - 484)

Hemopexin

Hemopexin: Hemopexin (489 - 532)

DUF3377

DUF3377: Domain of unknown function (DUF3377) (535 - 607)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 607 a.a.
Protein Preferred Names Protein Names

matrix metalloproteinase-16

  • MMP-16

Recombinant MMP16 Proteins

Cat. No. Product Name Accession Purity
HY-P79097 MMP-16 Protein, Human (I152N, His) P51512 (A32-G291, I152N) ≥ 95%, as determined by reducing SDS-PAGE.

MMP16 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811023 MMP16 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Seminoma

  • Seminoma, Pure
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Supraglottis Cancer

  • Malignant Tumor Of Supraglottis

  • Supraglottis

  • Ca Larynx - Supraglottis

  • Malignant Neoplasm Of Extrinsic Larynx

  • Malignant Neoplasm Of Supraglottis

  • Malignant Supraglottic Tumor

  • Neoplasm Of Supraglottis
Winchester Syndrome

  • WNCHRS

  • Winchester Disease

  • Winchester-Grossman Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS22645 Mmp16 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29159 Mmp16 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08532 MMP16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992267 Anti-MMP-16 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MMP16 VGNC VGNC:43278
Macaca mulatta MMP16 VGNC VGNC:74894
Mus musculus MMP16 MGD MGI:1276107
Rattus norvegicus MMP16 RGD RGD:620199
Felis catus MMP16 VGNC VGNC:68284
Bos taurus MMP16 VGNC VGNC:31521
Others MMP16 NCBI