2. Gene
  3. MMP16 - matrix metallopeptidase 16 Gene

MMP16 - matrix metallopeptidase 16 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MMP-X2; C8orf57; MT-MMP2; MT-MMP3; MT3-MMP

Gene ID: 4325 | Gene type: protein coding

About MMP16

Cytogenetic location: 8q21.3 Genomic coordinates (GRCh38): 8:88,032,011-88,327,483 (from NCBI)

This gene has 4 transcripts (splice variants), 271 orthologues and 23 paralogues. Biased expression in brain (RPKM 3.8), gall bladder (RPKM 1.9) and 12 other tissues.

Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]

MMP16 Products(1)

mRNA Protein Name
NM_005941.5 NP_005932.2 matrix metalloproteinase-16 precursor

MMP16 Protein Structure

PG_binding_1

PG_binding_1: Putative peptidoglycan binding domain (43 - 96)

Peptidase_M10

Peptidase_M10: Matrixin (126 - 291)

Hemopexin

Hemopexin: Hemopexin (355 - 390)

Hemopexin

Hemopexin: Hemopexin (392 - 435)

Hemopexin

Hemopexin: Hemopexin (439 - 484)

Hemopexin

Hemopexin: Hemopexin (489 - 532)

DUF3377

DUF3377: Domain of unknown function (DUF3377) (535 - 607)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 607 a.a.
Protein Preferred Names Protein Names

matrix metalloproteinase-16

MMP-16

Recombinant MMP16 Proteins

Cat. No. Product Name Accession Purity
HY-P79097 MMP-16 Protein, Human (I152N, His) P51512 (A32-G291, I152N) ≥95%

Related Diseases

Diseases Alias
Seminoma

Seminoma, Pure
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Supraglottis Cancer

Malignant Tumor Of Supraglottis

Supraglottis

Ca Larynx - Supraglottis

Malignant Neoplasm Of Extrinsic Larynx

Malignant Neoplasm Of Supraglottis

Malignant Supraglottic Tumor

Neoplasm Of Supraglottis
Winchester Syndrome

WNCHRS

Winchester Disease

Winchester-Grossman Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08532 MMP16 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MMP16 VGNC VGNC:43278
Macaca mulatta MMP16 VGNC VGNC:74894
Mus musculus MMP16 MGD MGI:1276107
Rattus norvegicus MMP16 RGD RGD:620199
Felis catus MMP16 VGNC VGNC:68284
Bos taurus MMP16 VGNC VGNC:31521
Others MMP16 NCBI