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MMP-7 Antibody

(Synonyms: Matrilysin; Matrilysin uterine; Matrin; Matrix Metalloproteinase 7; MMP-7; MMP 7; MMP7; MPSL1; PUMP 1; Pump 1 protease; PUMP1; Uterine Matrilysin; Uterine metalloproteinase; MMP7_HUMAN.)
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Based on 1 publication(s) in Google Scholar

MMP-7 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to MMP-7.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    IHC-P, IHC-F, ICC/IF, ELISA

  • Reactivity :

    Human, Mouse

  • Formulation:

    Supplied in 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

  • Conjugation:
    Non-conjugated
  • MMP-7 Antibody Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
IHC-F Info
IHC-F: Immunohistochemistry-Frozen
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
Dilution Ratio 1:5000-10000 1:100-500 1:100-500 1:100-500

Product Details

Description

MMP-7 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to MMP-7.

  • Host Rabbit
  • Clonality Polyclonal
  • Species Reactivity
    Human, Mouse Predicted Reactivity: Rat
    Info
    Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
  • Observed Molecular Weight
    Observed band size: 30 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 30 kDa
Species Reactivity Database
Immunogen

KLH conjugated synthetic peptide derived from human MMP7: 151-250/269

Sensitivity

Endogenous

Purification

affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3103218

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    MMP-7 (matrix metalloproteinase-7, matrilysin-1) is a secreted zinc-dependent endopeptidase that participates in extracellular matrix remodeling and the proteolytic processing of multiple non-matrix substrates, thereby influencing cell proliferation, apoptosis, epithelial repair, and tissue homeostasis[1]. Unlike many other matrix metalloproteinases, MMP-7 is one of the smallest family members and lacks the conserved C-terminal hemopexin domain, a structural distinction that contributes to its unique substrate profile and biological functions[1]. Mechanistically, Wnt/β-catenin signaling is a major upstream regulator of MMP-7 transcription, and MMP-7 is a well-established downstream target of β-catenin/TCF-mediated gene activation[2][3]. Through cleavage of substrates including E-cadherin, Fas ligand, and nephrin, MMP-7 regulates epithelial integrity, cell survival, epithelial-mesenchymal transition, and tissue remodeling processes[1]. In disease settings, elevated MMP-7 expression is associated with tumor progression, invasion, metastasis, and angiogenesis across multiple cancer types, while persistent induction of MMP-7 is also linked to kidney injury, fibrosis, and chronic kidney disease progression[1][4]. Compared with related isoforms such as MMP-2 and MMP-9, MMP-7 exhibits distinct biological activities; notably, MMP-7 can cleave nephrin and promote proteinuria, a function not reported for MMP-2 or MMP-9[1]. For experimental applications, selective MMP-7 inhibitors have recently demonstrated efficacy in reducing kidney fibrosis in preclinical models, supporting the use of MMP-7 as both a mechanistic target and a translational biomarker in disease research[4].

  • Subcellular Localization

    Secreted, extracellular space, extracellular matrix

  • SwissProt ID

    P09237

  • Gene ID
    4316 [NCBI]
  • Synonyms

    Matrilysin; Matrilysin uterine; Matrin; Matrix Metalloproteinase 7; MMP-7; MMP 7; MMP7; MPSL1; PUMP 1; Pump 1 protease; PUMP1; Uterine Matrilysin; Uterine metalloproteinase; MMP7_HUMAN.

[1]. Liu Z, et al. The Many Faces of Matrix Metalloproteinase-7 in Kidney Diseases. Biomolecules. 2020;10(6):960.

[2]. Chen YQ, et al. Induction of apoptosis and G2/M cell cycle arrest by DCC. Oncogene. 1999 Apr 29;18(17):2747-54. [Content Brief]

[3]. He W, et al. Matrix metalloproteinase-7 as a surrogate marker predicts renal Wnt/beta-catenin activity in CKD. J Am Soc Nephrol. 2012;23(2):294-304. [Content Brief]

[4]. Sarker AH, et al. DNA glycosylase NEIL2 functions in multiple cellular processes. Prog Biophys Mol Biol. 2021 Sep;164:72-80. [Content Brief]

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MMP-7 Antibody Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • MMP-7 Antibody Product Image