MMP7 - matrix metallopeptidase 7 Gene
Also Known as MMP-7; MPSL1; PUMP-1
Species: Homo sapiens
About MMP7
This gene has 3 transcripts (splice variants), 163 orthologues and 23 paralogues. Biased expression in gall bladder (RPKM 292.4), endometrium (RPKM 62.1) and 3 other tissues.
Summary
This gene encodes a member of the peptidase M10 family of Matrix Metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]
MMP7 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_002423.5 | NP_002414.1 | matrilysin preproprotein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables endopeptidase activity |
IDA
IDA: Inferred from direct assay
|
23845380 | GOA |
| enables metallopeptidase activity |
IDA
IDA: Inferred from direct assay
|
15297466 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
20812334 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| acts upstream of or within membrane protein ectodomain proteolysis |
IMP
IMP: Inferred from mutant phenotype
|
23437250 | GOA |
| acts upstream of or within membrane protein intracellular domain proteolysis |
IMP
IMP: Inferred from mutant phenotype
|
23437250 | GOA |
| involved in positive regulation of cell migration |
IDA
IDA: Inferred from direct assay
|
23437250 | GOA |
| involved in proteolysis |
IDA
IDA: Inferred from direct assay
|
15297466 | GOA |
MMP7 Protein Structure
PG_binding_1: Putative peptidoglycan binding domain (31 - 82)
Peptidase_M10: Matrixin (103 - 259)
- 0
- 100
- 200
- 267 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
matrilysin |
|
|
MMP7 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
MMP7 | P09237 | LGALS3 | Homo sapiens | P17931 | 20812334 | |
|
Intra
|
MMP7 | P09237 | LGALS3 | Homo sapiens | P17931 | 20812334 |
MMP7 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81117 | MMP-7 Antibody | IHC-P, IHC-F, ICC/IF, ELISA | Human, Mouse |
| HY-P86378 | MMP-7 Antibody (YA6070) | WB, IHC-P, ICC/IF, IP, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Breast Cancer |
|
|
| Endometriosis |
|
|
| Carotid Stenosis |
|
|
| Gastric Cancer |
|
|
| Cutis Laxa, Autosomal Dominant 3 |
|
|
| Multiple Sclerosis |
|
|
| Ovarian Cancer |
|
|
| Biliary Atresia |
|
|
| Lung Cancer |
|
|
| Cholangiocarcinoma |
|
|
| Prostate Cancer |
|
|
| Bronchiolitis Obliterans |
|
|
| Endometrial Cancer |
|
|
| Gastrointestinal Carcinoma |
|
|
| Pneumothorax |
|
|
| Adenoma |
|
|
| Cutis Laxa, Autosomal Dominant 2 |
|
|
| Colorectal Cancer |
|
|
| Rectum Cancer |
|
|
| Carcinosarcoma |
|
|
| Pancreatic Cancer |
|
|
| Interstitial Lung Disease 2 |
|
|
| Senile Ectropion |
|
|
| Esophageal Cancer |
|
|
| Macular Dystrophy, Patterned, 3 |
|
|
| Adenocarcinoma |
|
|
| Colonic Benign Neoplasm |
|
|
| Idiopathic Interstitial Pneumonia |
|
|
| Spastic Entropion |
|
|
| Pulmonary Fibrosis |
|
|
| Squamous Cell Carcinoma |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Entropion |
|
|
| Myocardial Infarction |
|
|
| Nonspecific Interstitial Pneumonia |
|
|
| Hepatocellular Carcinoma |
|
|
| Arthritis |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | MMP7 | MGD | MGI:103189 |
| Canis familiaris | MMP7 | VGNC | VGNC:43288 |
| Macaca mulatta | MMP7 | VGNC | VGNC:74901 |
| Felis catus | MMP7 | VGNC | VGNC:68290 |
| Bos taurus | MMP7 | VGNC | VGNC:31529 |
| Rattus norvegicus | MMP7 | RGD | RGD:3100 |
| Others | MMP7 | NCBI |