2. Metabolic Enzyme/Protease
  3. MMP
  4. Batimastat sodium salt

Batimastat sodium salt  (Synonyms: BB-94 sodium salt)

Cat. No.: HY-13564A Purity: 99.04%
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Batimastat sodium salt is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively.

For research use only. We do not sell to patients.

CAS No. : 130464-84-5

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Based on 16 publication(s) in Google Scholar

Other Forms of Batimastat sodium salt:

Batimastat sodium salt Related Antibodies

Top Publications Citing Use of Products

    Batimastat sodium salt purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Aug 6;16(1):592.  [Abstract]

    Representative images of migration capacity (boyden chamber assay) for L3.6pI cells treated or not with Batimastat (BB-94) (25 nM).

    Batimastat sodium salt purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2022 May 1;18(8):3167-3177.  [Abstract]

    Batimastat (BB-94) (10 μM; 24 h) abrogated the promotion of HepG2 and HeLa cells invasion by SNCG.

    Batimastat sodium salt purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2019 Nov 28;16(1):242.  [Abstract]

    Batimastat (MI) (50 ng/mL) supplement to the ACM increased Claudin-5, occludin, and ZO-1 levels of bEnd.3 cells.

    Batimastat sodium salt purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2019 Nov 28;16(1):242.  [Abstract]

    In the groups cultured with ACM from astrocytes exposed to OGD+RO, the additional Batimastat (MI) (50 ng/mL) treatment increased the TEER of the cell monolayer.

    Batimastat sodium salt purchased from MedChemExpress. Usage Cited in: Osteoarthritis Cartilage. 2019 Jan;27(1):148-157.  [Abstract]

    MMP-3-inhibitor Batimastat (1 μM; 6 h) significantly reduced the sGAG release from human OA explants.

    View All MMP Isoform Specific Products:

    View All Isoforms
    MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Batimastat sodium salt is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively.

    IC50 & Target

    IC50: 3 nM (MMP-1), 4 nM (MMP-2), 4 nM (MMP-9), 6 nM (MMP-7), 20 nM (MMP-3)[1]
    In Vitro

    Batimastat (BB-94) is a potent matrix metalloproteinase inhibitor, exhibits an unexpected mode of binding. Batimastat inhibits gelatinases A and B with IC50 values of 4 nM and 10 nM, respectively. The IC50 with the structurally similar collagenase Ht-d is 6 nM, which is comparable with values for MMP-1 (3 nM), MMP-8 (10 nM), and MMP-3 (20 nM)[2]. CD30 shedding from the cell line Karpas299 can effectively be blocked by the hydroxamic acidbased metalloproteinase inhibitor Batimastat (BB-94, IC50=230 nM)[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Batimastat sodium salt Related Antibodies
    In Vivo

    Intraperitoneal administration of Batimastat (BB-94) effectively blocks growth of human ovarian carcinoma xenografts and murine melanoma metastasis and delays the growth of primary tumors in an orthotopic model of human breast cancer without cytotoxicity and without affecting mRNA levels[2]. Batimastat (BB-94) is a synthetic matrix metalloproteinase inhibitor that has shown antineoplastic and antiangiogenic activity in various tumor models. Treatment with Batimastat (60 mg/kg i.p. every other day, for a total of eight injections) concomitantly with Cisplatin (4 mg/kg i.v., every 7 days for a total of three injections) completely prevents growth and spread of both xenografts, and all animals are alive and healthy on day 200[4]. Kaplan-Meier analysis of survival (at 48 h) shows that animals treated with Batimastat (BB-94) have increased survival (95.2%) in comparison with controls (75%), and differences are almost statistically significant (p=0.064)[5]. Matrix density is analyzed in saline- or Batimastat (40 mg/kg)-pretreated animals 4 h after E2 administration, the time point at which collagen density is observed to be at its lowest after hormone treatment[6].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    499.62

    Formula

    C23H30N3NaO4S2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C([C@@H]([C@@H](C(NO[Na])=O)CSC1=CC=CS1)CC(C)C)N[C@H](C(NC)=O)CC2=CC=CC=C2
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 3.57 mg/mL (7.15 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0015 mL 10.0076 mL 20.0152 mL
    5 mM 0.4003 mL 2.0015 mL 4.0030 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation
    References
    Animal Administration
    [5][6]

    Mice[5]
    Six-weeks-old female BALB/c mice are used. Mice are treated i.p. with Batimastat (BB-94, 50 mg/kg) 1 h before and 24 h post-infection. Batimastat is suspended at 50 mg/mL in DMSO and stored frozen at -20°C. Prior to use, it is diluted 20-fold in phosphate buffered saline (PBS), and 500 μL are injected into animals. Control mice are injected with 500 μL of 5% DMSO in PBS. Animals are sacrificed 48 h after i.c. challenge.
    Rats[6]
    Female Sprague-Dawley rats are administered a single physiological dose of E2 (40 μg/kg in a 0.9% NaCl, 0.4% EtOH vehicle) by intraperitoneal (i.p.) injection at the indicated time intervals prior to tissue collection at necropsy. This in vivo dose level of E2 has been shown to induce changes in uterine wet weight, tissue architecture, and gene expression characteristic of estrogen receptor activation. For all other experiments, animals are i.p. administered a single 40 μg/kg bolus of E2 4 h prior to tissue harvest, while control animals receive vehicle only in all studies. Batimastat is administered i.p. at a dose level (40 mg/kg in a 1× PBS, 0.1% Tween-20 vehicle) shown to be effective at inhibiting MMPs in vivo 4 h prior to E2 or saline control.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.0015 mL 10.0076 mL 20.0152 mL 50.0380 mL
    5 mM 0.4003 mL 2.0015 mL 4.0030 mL 10.0076 mL
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    Batimastat sodium salt Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Batimastat130464-84-5BB-94BB94BB 94MMPMatrix metalloproteinasesInhibitorinhibitorinhibit

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