MMP17 Antibody (YA1728)
(Synonyms: MMP17; MT4MMP; Matrix metalloproteinase-17; MMP-17; Membrane-type matrix metalloproteinase 4; MT-MMP 4; MTMMP4; Membrane-type-4 matrix metalloproteinase; MT4-MMP; MT4MMP)
Based on 1 Customer Validation
MMP17 Antibody (YA1728) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MMP17.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-1:2000 | 1:100-1:200 | 1:50-1:200 |
Product Details
MMP17 Antibody (YA1728) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MMP17.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 58 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 67 kDa
Entrez Gene: 4326 Human ; 23948 Mouse ; 288626 Rat
SwissProt: Q9ULZ9 Human ; Q9R0S3 Mouse ;
OMIM: 602285 Human
A synthesized peptide derived from human MMP17 aa150-210/603.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MMP-17, also known as membrane-type 4 matrix metalloproteinase (MT4-MMP), is a glycosylphosphatidylinositol (GPI) -anchored matrix metalloproteinase that localizes its catalytic activity to the cell surface and extracellular environment[1][2]. During development, MMP-17 shows regulated expression in vascular structures, neural tissues, and developing limbs, supporting roles in angiogenesis, neural crest cell migration, and tissue morphogenesis[2][3]. Mechanistically, MMP-17 participates in extracellular proteolysis and substrate processing, including cleavage of proteins such as osteopontin and pro-TNF, thereby influencing cellular signaling and tissue remodeling pathways[2]. In disease settings, MMP-17 has been implicated in inflammatory cartilage degradation, where genetic or pharmacological evidence links the enzyme to aggrecanolysis under inflammatory conditions[4][2]. MMP-17 also contributes to vascular homeostasis, and loss-of-function studies have associated reduced MMP-17 activity with altered vascular smooth muscle cell behavior and susceptibility to thoracic aortic aneurysm and dissection phenotypes[2]. Compared with related membrane-type MMP isoforms, MMP-17 is distinguished by its GPI anchor, limited extracellular matrix substrate repertoire, inability to activate pro-MMP-2, and greater sensitivity to TIMP-1 than TIMP-2, indicating a distinct regulatory and functional profile within the MT-MMP family[2][5]. For experimental applications, MMP-17 serves as a useful model for investigating cell-surface proteolysis, vascular remodeling, inflammatory tissue damage, and cancer-associated signaling pathways[2][6].
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Subcellular Localization
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side; Secreted, extracellular space, extracellular matrix
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Expression
Tissue_specificity:Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types -
Isoforms & Post-Translational Modification
Q9ULZ9 has 2 isomers: Q9ULZ9-1: 66653 Da (predicted); Q9ULZ9-2: 57938 Da (predicted).
The precursor is cleaved by a furin endopeptidase -
SwissProt ID
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Synonyms
MMP17; MT4MMP; Matrix metalloproteinase-17; MMP-17; Membrane-type matrix metalloproteinase 4; MT-MMP 4; MTMMP4; Membrane-type-4 matrix metalloproteinase; MT4-MMP; MT4MMP
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Research Field
Cardiovascular
Documentation
References
[1]. Itoh Y, et al. Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase. The Journal of Biological Chemistry. 1999 Nov;274(48):34260-34266. [Content Brief]
[2]. Yip C, et al. MT4-MMP: The GPI-Anchored Membrane-Type Matrix Metalloprotease with Multiple Functions in Diseases. Int J Mol Sci. 2019 Jan 16;20(2):354. [Content Brief]
[3]. Matrix-metalloproteinase-17. sciencedirect.topics.
[6]. Sohail A, et al. MT4-(MMP17) and MT6-MMP (MMP25), A unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancer. Cancer Metastasis Rev. 2008 Jun;27(2):289-302. [Content Brief]
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