MMP17 - matrix metallopeptidase 17 Gene

Also Known as MMP-17; MT4MMP; MTMMP4; MT4-MMP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4326

About MMP17

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:131,828,393-131,851,771 (from NCBI)

This gene has 9 transcripts (splice variants), 257 orthologues and 23 paralogues. Broad expression in brain (RPKM 3.8), skin (RPKM 1.6) and 16 other tissues.

Summary

This gene encodes a member of the peptidase M10 family and membrane-type subfamily of Matrix Metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein is unique among the membrane-type Matrix Metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers. [provided by RefSeq, Jan 2016]

MMP17 Products (13)

mRNA Protein Name
XM_047428862.1 XP_047284818.1 matrix metalloproteinase-17 isoform X6
XR_001748705.2
XM_047428860.1 XP_047284816.1 matrix metalloproteinase-17 isoform X4
XM_047428861.1 XP_047284817.1 matrix metalloproteinase-17 isoform X5
XR_944552.3
NM_016155.7 NP_057239.4 matrix metalloproteinase-17 isoform 1 precursor
XM_047428859.1 XP_047284815.1 matrix metalloproteinase-17 isoform X3
XM_011538355.4 XP_011536657.1 matrix metalloproteinase-17 isoform X1
XM_011538357.3 XP_011536659.1 matrix metalloproteinase-17 isoform X1
NM_001411000.1 NP_001397929.1 matrix metalloproteinase-17 isoform 2
XR_944551.3
XM_017019307.2 XP_016874796.1 matrix metalloproteinase-17 isoform X2
XM_011538356.4 XP_011536658.1 matrix metalloproteinase-17 isoform X1

MMP17 Protein Structure

PG_binding_1

PG_binding_1: Putative peptidoglycan binding domain (46 - 105)

Peptidase_M10

Peptidase_M10: Matrixin (132 - 295)

Hemopexin

Hemopexin: Hemopexin (336 - 379)

Hemopexin

Hemopexin: Hemopexin (385 - 428)

Hemopexin

Hemopexin: Hemopexin (431 - 477)

Hemopexin

Hemopexin: Hemopexin (480 - 521)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 603 a.a.
Protein Preferred Names Protein Names

matrix metalloproteinase-17

  • MT-MMP 4

  • matrix metallopeptidase 17 (membrane-inserted)

  • matrix metalloproteinase 17 (membrane-inserted)

  • membrane-type matrix metalloproteinase 4

  • membrane-type-4 matrix metalloproteinase

MMP17 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81983 MMP17 Antibody (YA1728) WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Male Breast Cancer

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Winchester Syndrome

  • WNCHRS

  • Winchester Disease

  • Winchester-Grossman Syndrome
Aortic Aneurysm, Familial Thoracic 1

  • Thoracic Aortic Aneurysm

  • Annuloaortic Ectasia

  • Familial Thoracic Aortic Aneurysm And Aortic Dissection

  • Familial Aortic Dissection

  • Familial Taad

  • Congenital Aneurysm Of Ascending Aorta

  • Familial Aortic Aneurysm

  • Familial Thoracic Aortic Aneurysm

  • Familial Thoracic Aortic Aneurysm And Dissection

  • Aortic Aneurysm, Thoracic

  • AAT1

  • Faa1

  • Aortic Dissection, Familial

  • Aortic Aneurysm, Familial Thoracic

  • Aneurysm, Thoracic Aortic

  • Faa

  • Ftaad

  • Taa

  • Taad

  • Cystic Medial Necrosis Of Aorta

  • Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection

  • Aortic Aneurysm Thoracic

  • Familial Aortic Aneurysms

  • Aneurysm, Aortic, Thoracic, Familial, Type 1

  • Aneurysm Of Thoracic Aorta

  • Intrathoracic Aneurysm

  • Thoracic Aorta Aneurysm

  • Thoracic Aortic Aneurysm Without Rupture

  • Thoracic Aneurysm

  • Thorax Arterial Aneurysm

  • Thoracic Artery Aneurysm

  • Thoracic Arterial Aneurysm

  • Thorax Aneurysm

  • Thorax Aortic Aneurysm

  • Dissection Of Thoracic Aorta
Arthritis

  • Inflammatory Joint Disease

  • Inflammatory Disorder Of Joint
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110397 KP-457 Inhibitor 99.18% Unkown
HY-110397G KP-457 (GMP) Inhibitor / Unkown
HY-RS08533 MMP17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08534 Mmp17 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08535 Mmp17 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180115 Antibacterial agent 315 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MMP17 VGNC VGNC:59062
Mus musculus MMP17 MGD MGI:1346076
Bos taurus MMP17 VGNC VGNC:31522
Rattus norvegicus MMP17 RGD RGD:1311541
Macaca mulatta MMP17 VGNC VGNC:74895
Felis catus MMP17 VGNC VGNC:68285
Others MMP17 NCBI