1. Metabolic Enzyme/Protease
  2. MMP
  3. ND-336

ND-336 

Cat. No.: HY-124373
Handling Instructions

ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2, MMP-9, and MMP-14, with Kis of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound.

For research use only. We do not sell to patients.

ND-336 Chemical Structure

ND-336 Chemical Structure

CAS No. : 1807453-83-3

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Description

ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2, MMP-9, and MMP-14, with Kis of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound[1][2].

IC50 & Target[1]

MMP-2

85 nM (Ki)

MMP-9

150 nM (Ki)

MMP-14

120 nM (Ki)

In Vivo

ND-336 accelerates diabetic wound healing by decreasing inflammation and by enhancing angiogenesis and re-epithelialization of the wound, thus reversing the pathological condition[1].
ND-336 (0.05-0.01 mg; topical application; daily for 14 day) accelerates diabetic wound healing[1].

Animal Model: Female diabetic db/db mice[1]
Dosage: 0.05, 0.025, and 0.01 mg
Administration: Topical application; daily for 14 day
Result: Healed 1.2- to 1.6-fold faster than those treated with ND-322 than those treated with vehicle.
Molecular Weight

371.90

Formula

C₁₆H₁₈ClNO₃S₂

CAS No.

1807453-83-3

SMILES

NCC1=CC=C(OC2=CC=C(C=C2)S(CC3SC3)(=O)=O)C=C1.Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ND-336ND336ND 336MMPMatrix metalloproteinaseswoundhealinginflammationangiogenesisselectivediabeticInhibitorinhibitorinhibit

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ND-336
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HY-124373
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