1807453-83-3
1807453-83-3
Chemical Structure
ND-336
- CAS. Nr.: 1807453-83-3
- Formula:C16H18ClNO3S2
- Molecular Weight:371.90
IUPAC Name: (4-(4-((thiiran-2-ylmethyl)sulfonyl)phenoxy)phenyl)methanamine hydrochloride
InChIKey: DRGIZFGSEKSFIC-UHFFFAOYSA-N
SMILES: NCC1=CC=C(OC2=CC=C(C=C2)S(CC3SC3)(=O)=O)C=C1.Cl
Biological Activity: ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2, MMP-9, and MMP-14, with Kis of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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ND-336 | 97.16% | ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2, MMP-9, and MMP-14, with Kis of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound. | ||||||||||||||||||||
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References
- [1]. Gao M, et al. Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy. Proc Natl Acad Sci U S A. 2015;112(49):15226-15231. [Content Brief]
- [2]. Nguyen TT, et al. Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing. J Med Chem. 2018;61(19):8825-8837. [Content Brief]
