1. Metabolic Enzyme/Protease
  2. MMP
  3. (R)-ND-336


Cat. No.: HY-124373A
Handling Instructions

(R)-ND-336 is a potent and selective MMP-9 inhibitor with a Ki of 19 nM. (R)-ND-336 inhibits MMP-2 (Ki=127 nM) and MMP-14 (Ki=119 nM). (R)-ND-336 has the potential for diabetic foot ulcers (DFUs) research.

For research use only. We do not sell to patients.

(R)-ND-336 Chemical Structure

(R)-ND-336 Chemical Structure

CAS No. : 2252493-33-5

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of (R)-ND-336:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


(R)-ND-336 is a potent and selective MMP-9 inhibitor with a Ki of 19 nM. (R)-ND-336 inhibits MMP-2 (Ki=127 nM) and MMP-14 (Ki=119 nM). (R)-ND-336 has the potential for diabetic foot ulcers (DFUs) research[1].

IC50 & Target[1]


19 nM (Ki)


127 nM (Ki)


119 nM (Ki)

In Vitro

(R)-ND-336 poorly inhibits other MMPs (Ki>100 μM). (R)-ND-336 has a long residence time (the time the inhibitor is bound to MMP-9, calculated as 1/koff) of 300 min[1].
A favorable IC50value of 143 μM afforded a therapeutic index (IC50/Ki for MMP-9) ratio of 7530, indicating that (R)-ND-336 is not cytotoxic[1].

In Vivo

(R)-ND-336 (50 μg/wound/day for 14 days) accelerates wound healing faster[1].
(R)-ND-336 has an AUC of 1.3 μM•min after topical administration and 35 μM•min following intravenous dosing, for an AUCtop/AUCiv ratio of 3.7%, indicating minimal absorption after topical administration in db/db mice[1].

Animal Model: Female db/db mice (BKS.Cg-Dock7m+/+Leprdb/J, 8-weeks old, ∼40 g body weight)[1]
Dosage: 50 μg
Administration: Wound; once a day for 14 days
Result: Accelerated wound healing faster and showed complete inhibition of MMP-9.
Molecular Weight







NCC1=CC=C(OC2=CC=C(C=C2)S(C[[email protected]@H]3SC3)(=O)=O)C=C1.Cl


Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2


(R)-ND-336MMPMatrix metalloproteinasesdiabeticfootulcersDFUswoundInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name



Applicant Name *


Email address *

Phone number *


Organization name *

Country or Region *


Requested quantity *


Bulk Inquiry

Inquiry Information

Product Name:
Cat. No.:
MCE Japan Authorized Agent: