(R)-ND-336
(R)-ND-336 is a potent and selective MMP-9 inhibitor with a Ki of 19 nM. (R)-ND-336 inhibits MMP-2 (Ki=127 nM) and MMP-14 (Ki=119 nM). (R)-ND-336 has the potential for diabetic foot ulcers (DFUs) research.
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- CAS No.: 2252493-33-5
- Formule: C16H18ClNO3S2
- Masse moléculaire:371.90
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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MMP-9 19 nM (Ki) |
MMP-2 127 nM (Ki) |
MMP-14 119 nM (Ki) |
(R)-ND-336 poorly inhibits other MMPs (Ki>100 μM). (R)-ND-336 has a long residence time (the time the inhibitor is bound to MMP-9, calculated as 1/koff) of 300 min[1].
A favorable IC50value of 143 μM afforded a therapeutic index (IC50/Ki for MMP-9) ratio of 7530, indicating that (R)-ND-336 is not cytotoxic[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
(R)-ND-336 has an AUC of 1.3 μM min after topical administration and 35 μM min following intravenous dosing, for an AUCtop/AUCiv ratio of 3.7%, indicating minimal absorption after topical administration in db/db mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female db/db mice (BKS.Cg-Dock7m+/+Leprdb/J, 8-weeks old, ∼40 g body weight)[1]
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Dosage:50 μg
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Administration:Wound; once a day for 14 days
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Result:Accelerated wound healing faster and showed complete inhibition of MMP-9.
Chemical Information
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CAS No. 2252493-33-5
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Masse moléculaire 371.90
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Formule C16H18ClNO3S2
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SMILES
NCC1=CC=C(OC2=CC=C(C=C2)S(C[C@@H]3SC3)(=O)=O)C=C1.Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(R)-ND-336 Related Classifications
HY-124373A Related Classifications
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