diABZI-i
diABZI-i is an orthogonal STING inhibitor. diABZI-i significantly inhibits cGAMP-induced IFNβ in PBMCs. diABZI-i also activates constitutive signaling of V155M SAVI and exerts potent agonistic effects in the STING V155M THP-1 cell model. diABZI-i can be used for research on monogenic autoinflammatory diseases such as SAVI.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C45H50N12O6
- 分子量:854.96
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
diABZI-i (1.3 nM-50 μM; 24 h) potently inhibits cGAMP-induced β-interferon production in human peripheral blood mononuclear cells (PBMCs), with an IC50 of 49 nM[1].
diABZI-i inhibits the cGAMP-induced interferon signaling pathway in wild-type THP-1 cells, with an IC50 of 3 μM and a maximum inhibition rate >95%[1].
diABZI-i potently activates the constitutive interferon signaling pathway in STINGV155M-mutant THP-1 cells, with an EC50 of 17 nM, rather than inhibiting this signaling pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 854.96
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分子式 C45H50N12O6
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SMILES
CCN1N=CC=C1C(/N=C2N(C3=C(N\2C/C(C)=C(CN4C5=C(C=C(C=C5N(/C4=N\C(C6=CC(C)=NN6CC)=O)C)C(N)=O)OCC7=CC=CC(OC)=C7)\C)C=CC(C(N)=O)=C3)C)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
diABZI-i 関連分類
HY-175167 関連分類
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Keywords
- diABZI-i
- STING
- IFNAR
- Stimulator of Interferon Genes
- TMEM173
- MITA
- ERIS
- MPYS
- Interferon-α/β receptor
- Interferon-alpha/beta receptor
- human STING155-341 G230A/R293Q
- cGAMP
- human STING155-341 G230A/H232R/R293Q
- sting-associated vasculopathy with onset in infancy
- THP-1 cells
- interferon beta
- V155M SAVI mutant STING
- STING V155M mutant THP-1 cells
- human PBMCs
- Inhibitor
- inhibitor
- inhibit