diABZI-i
diABZI-i is an orthogonal STING inhibitor. diABZI-i significantly inhibits cGAMP-induced IFNβ in PBMCs. diABZI-i also activates constitutive signaling of V155M SAVI and exerts potent agonistic effects in the STING V155M THP-1 cell model. diABZI-i can be used for research on monogenic autoinflammatory diseases such as SAVI.
For research use only. We do not sell to patients.
- Formula: C45H50N12O6
- Molecular Weight:854.96
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
diABZI-i (1.3 nM-50 μM; 24 h) potently inhibits cGAMP-induced β-interferon production in human peripheral blood mononuclear cells (PBMCs), with an IC50 of 49 nM[1].
diABZI-i inhibits the cGAMP-induced interferon signaling pathway in wild-type THP-1 cells, with an IC50 of 3 μM and a maximum inhibition rate >95%[1].
diABZI-i potently activates the constitutive interferon signaling pathway in STINGV155M-mutant THP-1 cells, with an EC50 of 17 nM, rather than inhibiting this signaling pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 854.96
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Formula C45H50N12O6
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SMILES
CCN1N=CC=C1C(/N=C2N(C3=C(N\2C/C(C)=C(CN4C5=C(C=C(C=C5N(/C4=N\C(C6=CC(C)=NN6CC)=O)C)C(N)=O)OCC7=CC=CC(OC)=C7)\C)C=CC(C(N)=O)=C3)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
diABZI-i Related Classifications
HY-175167 Related Classifications
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