Antiangiogenic agent 10
Antiangiogenic agent 10 is a potent orally active antiangiogenic agent with antiproliferative activity against breast cancer cells. Antiangiogenic agent 10 induces apoptosis via caspase-3 activation. Antiangiogenic agent 10 can be used for the research of breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 3091622-68-0
- Formula: C20H15F3N2O3S
- Molecular Weight:420.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Antiangiogenic agent 10 (compound 10a) (1-100 μM; 24 h) inhibits the proliferation of MCF-7 breast cancer cells with an IC50 of 28.77 μM and MDA-MB-231 breast cancer cells with an IC50 of 32.34 μM[1].
Antiangiogenic agent 10 (1-100 μM; 24 h) activates caspase-3 and promoting apoptosis in MCF-7 breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7, MDA-MB-231 cells
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Concentration:1; 3; 10; 30; 100 μM
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Incubation Time:24 h
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Result:Inhibited MCF-7 cell proliferation with an IC50 of 28.77 μM.
Inhibited MDA-MB-231 cell proliferation with an IC50 of 32.34 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar Rats (female, 180-230 g)[1]
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Dosage:5; 50; 300; 2000 mg/kg
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Administration:i.g.; single dose
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Result:Showed no mortality across all doses over 14 days.
Caused hard abdomen and periodic body stretching in the first 48 hours at the 2000 mg/kg dose.
Induced dose-dependent weight loss: final mean body weight was 195 g at 5 mg/kg, 197 g at 50 mg/kg, 180 g at 300 mg/kg, 175 g at 2000 mg/kg.
Showed no significant changes in food or water consumption.
Chemical Information
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CAS No. 3091622-68-0
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Molecular Weight 420.40
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Formula C20H15F3N2O3S
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SMILES
O=S(NC(NC(C=C1)=CC=C1C2=CC=CC=C2)=O)(C3=CC=C(C(F)(F)F)C=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antiangiogenic agent 10 Related Classifications
HY-183779 Related Classifications
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