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Cat. No.: HY-N13141

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Tetracenomycin X

Tetracenomycin X is a natural aromatic polyketide compound. Tetracenomycin X can inhibit peptide bond formation between an incoming aminoacyl-tRNA and a terminal Gln-Lys (QK) motif in the nascent polypeptide. Tetracenomycin X can be used for the development of novel aromatic polyketide antibiotics .

For research use only. We do not sell to patients.

CAS No.: 121245-07-6
Formula: C₂₄H₂₂O₁₁
Molecular Weight:486.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Tetracenomycin X Chemical Structure

CAS No.: 121245-07-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	1.6 μM Compound: Tetracenomycin X	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 26317881]
K562	IC₅₀	5.2 μM Compound: Tetracenomycin X	Cytotoxicity against human K562 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Cytotoxicity against human K562 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 26317881]
MCF7	IC₅₀	1.5 μM Compound: Tetracenomycin X	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay	[PMID: 26317881]

Chemical Information

CAS No. 121245-07-6
Molecular Weight 486.42
Formula C₂₄H₂₂O₁₁
SMILES

CO[C@@]12[C@@](C(C(C(C1=O)=C(C3=C4C)O)=CC3=CC(OC)=C4C(OC)=O)=O)([C@@H](C(OC)=CC2=O)O)O
Structure Classification
- Others
Initial Source
- Microorganisms
Saccharothrix sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Leroy EC, et al. Tetracenomycin X sequesters peptidyl-tRNA during translation of QK motifs. Nat Chem Biol. 2023 Sep;19(9):1091-1096. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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