GPR15L Protein, Human (His, Myc)

GPR15L Protein, Human (His, Myc) is the recombinant human-derived GPR15L protein, expressed by E. coli, with N-10*His & C-Myc tag.

GPR15L is a highly cationic multifunctional protein. It acts as a chemotactic factor mediating lymphocyte recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15. This protein may function as a tumor suppressor, exhibiting growth inhibitory effects on colon cancer cells in conjunction with SUSD2, including induction of G1 cell cycle arrest. GPR15L potentially regulates keratinocyte proliferation. Additionally, by activating Mas-related G protein-coupled receptors (MRGPRs), it contributes to pruritogenesis through activation of itch-selective sensory neurons and mast cell degranulation. by similar: Studies also suggest its significant roles in immune modulation and sensory nerve regulation.

Human

E. coli

N-10*His;C-Myc

Q6UWK7 (K25-V81)

387695

Full Length of Mature Protein

KRRPAKAWSGRRTRLCCHRVPSPNSTNLKGHHVRLCKPCKLEPEPRLWVVPGALPQV

Approximately 16 kDa,based on SDS-PAGE under reducing conditions.

≥ 90%, as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, 6% trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O . For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.