2. Metabolic Enzyme/Protease Stem Cell/Wnt
  3. MMP SDCBP
  4. AG73

AG73 is a polypeptide. AG73 is derived from the G domain of the Laminin α1 chain. AG73 binds heparin, Syndecan-1 and Syndecan-4. AG73 promotes the adhesion of various cells, induces the differentiation of salivary gland acinar cells, stimulates neurite outgrowth, secretion of matrix metalloproteinases and angiogenesis. AG73 retains its angiogenic activity when conjugated to chitosan membranes. AG73 can be used in the research of melanoma and ischemic injury.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

AG73

AG73 Chemical Structure

CAS No. : 170655-66-0

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AG73 Related Antibodies

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Description

AG73 is a polypeptide. AG73 is derived from the G domain of the Laminin α1 chain. AG73 binds heparin, Syndecan-1 and Syndecan-4. AG73 promotes the adhesion of various cells, induces the differentiation of salivary gland acinar cells, stimulates neurite outgrowth, secretion of matrix metalloproteinases and angiogenesis. AG73 retains its angiogenic activity when conjugated to chitosan membranes. AG73 can be used in the research of melanoma and ischemic injury[1][2][3].

In Vitro

AG73 (200 μg/mL) completely inhibits the formation of cellular networks by mouse melanoma (B16F10) cells on Matrigel[1].
AG73 binds to immobilized biotinylated heparin with a Kd of 6.4 μM[1].
AG73 (1-100 μg/mL; 2 days) stimulates angiogenesis sprouting from 13-day-incubated chick embryo aortic rings in a dose-dependent manner[2].
AG73 (0.1-100 μg; 18 h) promotes axonal growth in 71% of PC12 cells when used at a substrate coating concentration of 100 μg[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AG73 Related Antibodies
In Vivo

AG73 (0.5 μg per coverslip; topical application; single dose) acts as an angiogenic factor in vivo, inducing a positive angiogenic response in 55.5% of chick embryos in the CAM assay[2].
AG73 (1 mg/mL per mouse; s.c.; single dose) promotes vessel cell migration and angiogenesis in vivo, resulting in a mean of 55 endothelial cells per field in the subcutaneous Cultrex BME plug assay[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: unspecified strain (fertilized eggs)[2]
Dosage: 0.5 μg per coverslip
Administration: topical application; single dose
Result: Induced a positive angiogenic response (vessels radiating from the coverslip center) in 55.5% of treated eggs.
Animal Model: unspecified strain[2]
Dosage: 1 mg/mL per mouse
Administration: s.c.; single dose
Result: Showed an intermediate color between the poorly vascularized control/AG73T plugs and the ECGS-treated positive control plugs.
Confirmed significantly more migrated endothelial cells, with a mean of ~55 endothelial cells per field.
Molecular Weight

1497.82

Formula

C64H120N24O17
CAS No.
Sequence

Arg-Lys-Arg-Leu-Gln-Val-Gln-Leu-Ser-Ile-Arg-Thr
Sequence Shortening

RKRLQVQLSIRT
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AG73 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AG73170655-66-0AG 73AG-73MMPSDCBPMatrix metalloproteinasesSyntenin Syndecan Binding Protein (SDCBP)/MDA-9laminin-1 E3 fragmentischemic injuriesmelanomaPC12 cellssyndecan-4syndecan-1murine endothelial SVEC4-10 cellshuman salivary gland (HSG) cellsmouse melanoma (B16F10) cellschick embryo aortic ringsInhibitorinhibitorinhibit

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