170655-66-0
Chemical Structure
AG73
- CAS No.: 170655-66-0
- Formula:C64H120N24O17
- Molecular Weight:1497.82
IUPAC Name: L-arginyl-L-lysyl-L-arginyl-L-leucyl-L-glutaminyl-L-valyl-L-glutaminyl-L-leucyl-L-seryl-L-isoleucyl-L-arginyl-L-threonine
InChIKey: ZMQAYVPRLVWKNK-OWDRPFSUSA-N
SMILES: [C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)N)=O)CCCCN)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCC(N)=O)=O)C(C)C)=O)CCC(N)=O)=O)CC(C)C)=O)CO)=O)[C@H](CC)C)=O)(C(N[C@@H]([C@@H](C)O)C(O)=O)=O)CCCNC(=N)N
Biological Activity: AG73 is a polypeptide. AG73 is derived from the G domain of the Laminin α1 chain. AG73 binds heparin, Syndecan-1 and Syndecan-4. AG73 promotes the adhesion of various cells, induces the differentiation of salivary gland acinar cells, stimulates neurite outgrowth, secretion of matrix metalloproteinases and angiogenesis. AG73 retains its angiogenic activity when conjugated to chitosan membranes. AG73 can be used in the research of melanoma and ischemic injury[1][2][3].
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AG73 | AG73 is a polypeptide. AG73 is derived from the G domain of the Laminin α1 chain. AG73 binds heparin, Syndecan-1 and Syndecan-4. AG73 promotes the adhesion of various cells, induces the differentiation of salivary gland acinar cells, stimulates neurite outgrowth, secretion of matrix metalloproteinases and angiogenesis. AG73 retains its angiogenic activity when conjugated to chitosan membranes. AG73 can be used in the research of melanoma and ischemic injury. | |||||||||||||||||||||
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- [1]. Hoffman MP, et al. Cell type-specific differences in glycosaminoglycans modulate the biological activity of a heparin-binding peptide (RKRLQVQLSIRT) from the G domain of the laminin alpha1 chain. J Biol Chem. 2001;276(25):22077-22085. [Content Brief]
- [2]. Mochizuki M, et al. Angiogenic activity of syndecan-binding laminin peptide AG73 (RKRLQVQLSIRT). Arch Biochem Biophys. 2007;459(2):249-255. [Content Brief]
- [3]. Weeks BS, et al. Laminin-1 and the RKRLQVQLSIRT laminin-1 alpha1 globular domain peptide stimulate matrix metalloproteinase secretion by PC12 cells. Exp Cell Res. 1998;243(2):375-382. [Content Brief]
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