22-(4′-py)-JA
22-(4′-py)-JA is a semisynthetic derivative of junamycin A (JA) that can be isolated from the Thai blue sponge (Xestospongia sp.). 22-(4′-py)-JA has antimetastatic activity and can inhibit AKT/mTOR/p70S6K signaling. 22-(4′-py)-JA inhibits tumor cell invasion and tube formation in human umbilical vein endothelial cells (HUVEC), downregulates metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF). 22-(4′-py)-JA has potent anticancer activity against non-small cell lung cancer (NSCLC).
For research use only. We do not sell to patients.
- CAS No.: 1178895-15-2
- Formula: C32H30N4O8
- Molecular Weight:598.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
10 nM
Compound: 9a
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Cytotoxicity against human HCT116 cells after 3 days by MTT assay
Cytotoxicity against human HCT116 cells after 3 days by MTT assay
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[PMID: 19457672] |
| MDA-MB-435 | IC50 |
4.4 nM
Compound: 9a
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Cytotoxicity against human MDA-MB-435 cells after 3 days by MTT assay
Cytotoxicity against human MDA-MB-435 cells after 3 days by MTT assay
|
[PMID: 19457672] |
Chemical Information
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CAS No. 1178895-15-2
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Molecular Weight 598.60
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Formula C32H30N4O8
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SMILES
O=C(C1=C(C2=O)C[C@@]3([H])[C@H](C#N)N4[C@@H](COC(C5=CC=NC=C5)=O)C(C(C(OC)=C(C)C6=O)=O)=C6C[C@@]4([H])[C@@]([H])1N3C)C(OC)=C2C
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Synonyms
22-4′-Pyridinecarbonyl jorunnamycin A
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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