Ianalumab
Based on 1 Customer Validation
Ianalumab (VAY-736) is a human, decarboxylated antibody against BAFF-R. Ianalumab can block the interaction between BAFF and BAFF-R and antagonize the apoptosis protection mediated by BAFF. Ianalumab exerts antibody-dependent cytotoxic (ADCC), depending on effector cell activation mediated by immune receptor tyrosine activation motif (ITAM).
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 1929549-92-7
- Molecular Weight:146.44 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human IgG1 kappa
Human
TNFRSF13C/BAFFR/CD268
Ianalumab (0.1 μg/mL; 72 h) shows enhanced ADCC and cytokine production induction by chronic lymphocytic leukemia (CLL) NK cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ianalumab (10 mg/kg; once weekly for 6 weeks) is enhanced by Ibrutinib (HY-10997) through an ITAM function on NK cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Em-TCL1 adoptive transplant model of murine CLL[1]
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Dosage:10 mg/kg
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Administration:Injection; once weekly for 6 weeks
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Result:Ibrutinib enhanced VAY-736 activity through an ITAM function on NK cells.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized Human BAFFR / TNFRSF13C, Fc Tag can bind Ianalumab. The EC50 for this effect is 10.75 ng/mL. -
Flow Cytometry analysis of Raji cells labelling TNFRSF13C/BAFFR/CD268 (red) with Ianalumab (anti-TNFRSF13C/BAFFR/CD268) (HY-P99653). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.
Chemical Information
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CAS No. 1929549-92-7
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Appearance Liquid
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Molecular Weight 146.44 kDa
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Color Colorless to light yellow
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SMILES
[Ianalumab]
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Synonyms
VAY-736
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (259 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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