TNFRSF13C - TNF receptor superfamily member 13C Gene

Homo sapiens

Also known as BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin

Gene ID: 115650 | Gene type: protein coding

About TNFRSF13C

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,922,032-41,926,806 (from NCBI)

This gene has 1 transcript (splice variant), 91 orthologues, 1 paralogue and is associated with 3 phenotypes. Biased expression in spleen (RPKM 19.7), lymph node (RPKM 17.1) and 5 other tissues.

Summary

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]

TNFRSF13C Products(1)

mRNA	Protein	Name
NM_052945.4	NP_443177.1	tumor necrosis factor receptor superfamily member 13C

TNFRSF13C Protein Structure

BaffR-Tall_bind

0
100
184 a.a.

Protein Preferred Names

Protein Names

tumor necrosis factor receptor superfamily member 13C

B cell-activating factor receptor

Recombinant TNFRSF13C Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7130	BAFFR/TNFRSF13C Protein, Human	Q96RJ3 (M1-G76)	≥95%
HY-P72764	BAFFR/TNFRSF13C Protein, Human (HEK293, His)	Q96RJ3 (S7-A71)	≥95%
HY-P78065	BAFFR/TNFRSF13C Protein, Human (Biotinylated, HEK293, His-Avi)	Q96RJ3 (S7-A71)	≥95%
HY-P700453	BAFFR/TNFRSF13C Protein, Human (HEK293, hFc-Flag)	Q96RJ3 (S7-A71)	≥95%

Related Diseases

Diseases

Alias

Immunodeficiency, Common Variable, 4

CVID4	Antibody Deficiency Due To Baffr Defect
Common Variable Immunodeficiency 4	Immunodeficiency, Variable, Common, Type 4

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Immunodeficiency, Common Variable, 2

CVID2	Antibody Deficiency Due To Taci Defect
Hypogammaglobulinemia Due To Taci Deficiency	Common Variable Immunodeficiency 2
Immunodeficiency, Variable, Common, Type 2

Primary Agammaglobulinemia

Immunoglobulin Deficiency	Antibody Deficiency Syndrome
Antibody	Antibody Deficiency
Gammaglobulin Deficiency	Antibody Deficiency With Near-Normal Immunoglobulins Or With Hyperimmunoglobulinaemia
Immunoglobulin Deficiency With Near-Normal Immunoglobins	Immunoglobulin Deficiency With Hyperimmunoglobulinaemia
Antibody Immunodeficiency With Hyperimmunoglobulinaemia	Antibody Deficiency With Hyperimmunoglobulinaemia

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Follicular Lymphoma

Lymphoma, Follicular	Lymphoma Follicular
Brill-Symmers' Disease	Large Cell Follicular Non-Hodgkin Lymphoma
Diffuse Follicle Centre Lymphoma	Diffuse Follicular Lymphoma Nos
Follicular Nodular Non-Hodgkin Lymphoma, Unspecified	Follicular Large Cell Cleaved Or Noncleaved Lymphoma
Large Cell Follicular Noncleaved Lymphoma	Follicular Lymphoma With Or Without Diffuse Areas
Histiocytic Follicular Lymphoma	Histiocytic Nodular Lymphoma
Histiocytic Nodular Malignant Lymphoma	Large Cell Follicular Lymphoma
Large Cell Noncleaved Follicular Lymphoma	Large Cell Noncleaved Follicular Malignant Lymphoma
Nodular Reticulum Cell Sarcoma	Noncleaved Follicular Lymphoma

Macroglobulinemia

Primary Macroglobulinemia

Waldenstrom Macroglobulinemia

Transient Hypogammaglobulinemia Of Infancy

Immunoglobulin Maturational Delay

Thi - [Transient Hypogammaglobulinaemia Of Infancy]

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Cd40 Ligand Deficiency

X-Linked Hyper Igm Syndrome	Hyperimmunoglobulin M Syndrome
Higm1	Hyper-Igm Syndrome Type 1
X-Linked Hyper-Igm Syndrome	Xhigm
Higmx-1	X-Linked Hyper-Igm Immunodeficiency
Hyper-Igm Syndrome 1	Immunodeficiency With Hyper-Igm, Type 1
Hyper-Igm Syndrome Due To Cd40 Ligand Deficiency	Hyper-Igm Syndrome Due To Cd40l Deficiency
Hyper-Igm Immunodeficiency Syndrome	Hyper-Igm Immunodeficiency Syndrome, Type 1

Transient Hypogammaglobulinemia

Trypanosomiasis

B Cell Deficiency

Immunoglobulin Heavy Chain Deficiency	B Cell Deficiencies
Immunoglobulin Heavy Chain Deletion	Humoral Immune Defect

Selective Igg Deficiency Disease

Igg Deficiency	Immunoglobin G Subclass Deficiency
Selective Deficiency Of Igg	Selective Igg Immunodeficiency
Selective Immunoglobulin G Deficiency	Selective Immunoglobulin G Subclass Deficiency

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma	Lymphoma, Non-Hodgkin
NHL	Lymphoma, Non-Hodgkin, Somatic
Lymphoma, Follicular, Somatic	Familial Non-Hodgkin Lymphoma
Lymphoma Non-Hodgkins	Follicular Lymphoma, Somatic
Lymphosarcoma	Non-Hodgkins Lymphoma

Immunodeficiency With Hyper-Igm, Type 4

HIGM4	Hyper-Igm Syndrome Type 4
Immunodeficiency With Hyper-Igm Type 4	Hyper-Igm Syndrome 4
Immunodeficiency With Hyper Igm Type 4	Hyper Igm Syndrome 4
Immunodeficiency, With Hyper Igm, Type 4

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Immunoglobulin Alpha Deficiency

Iga Deficiency	Gamma-A-Globulin Deficiency
Immunoglobulin A Deficiency

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome	Chromosome 11p11.2 Deletion Syndrome
Pss	11p11.2 Deletion
P11pds	Defect11 Syndrome
Deletion Of Chromosome 11p11.2	POSHS

Immunodeficiency With Hyper-Igm, Type 3

HIGM3	Immunodeficiency With Hyper Igm Type 3
Hyper-Igm Syndrome Type 3	Hyper-Igm Syndrome 3
Hyper-Igm Syndrome Due To Cd40 Deficiency	Cd40 Deficiency
Type 3 Hyper-Igm Immunodeficiency	Hyper Igm Syndrome 3
Immunodeficiency With Hyper-Igm 3	Hyper-Igm Immunodeficiency Type 3
Immunodeficiency, With Hyper Igm, Type 3	Hyper-Igm Immunodeficiency Syndrome, Type 3

Immunodeficiency With Hyper-Igm, Type 1

Immunodeficiency, X-Linked, With Hyper-Igm	Hyper Igm Syndrome
HIGM1	Xhim
Hyper-Igm Syndrome	Higm
Hyper-Igm Syndrome 1	Immunodeficiency 3
Imd3	Immunodeficiency With Hyper-Igm
Immunodeficiency With Hyper Igm Type 1	Ihis
X-Linked Hyper Igm Syndrome	Hyper-Igm Immunodeficiency, X-Linked
Hyper Igm Immunodeficiency, X-Linked	Hyper Igm Syndrome 1
X-Linked Immunodeficiency With Hyper-Igm 1	Immunodeficiency, With Hyper Igm
Immunodeficiency, With Hyper Igm, Type 1	Hyper-Igm Immunodeficiency Syndrome, Type 1
Hyperimmunoglobulin M Syndrome

Good Syndrome

Immunodeficiency With Thymoma	Thymoma-Immunodeficiency Syndrome
Thymoma With Hypogammaglobulinemia	Thymoma Immunodeficiency

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Lymphoid Interstitial Pneumonia

Lymphocytic Interstitial Pneumonia	Lip Disease
Lip Diseases	LIP
Disease Of Lips

Autoimmune Disease Of Exocrine System

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma	Gastric Lymphoma, Primary
Lymphoma, Malt, Somatic	Mucosa-Associated Lymphoid Tissue Lymphoma
Extranodal Marginal Zone B-Cell Lymphoma	MALTOMA
Marginal Zone B-Cell Lymphoma	Mucosa-Associated Lymphatic Tissue Lymphoma
Primary Gastric Lymphoma	Gastric Lymphoma
Familial Primary Gastric Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14805	TNFRSF13C Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TNFRSF13C	VGNC	VGNC:54377
Felis catus	TNFRSF13C	VGNC	VGNC:66405
Bos taurus	TNFRSF13C	VGNC	VGNC:57365
Macaca mulatta	TNFRSF13C	VGNC	VGNC:108067
Mus musculus	TNFRSF13C	MGD	MGI:1919299
Rattus norvegicus	TNFRSF13C	RGD	RGD:1560810
Macaca fascicularis	TNFRSF13C	NCBI
Others	TNFRSF13C	NCBI

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