2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. GABAA receptor agent 6

GABAA receptor agent 6 (compound 2027) is a potent γ-GABAAR antagonist with an Ki of 0.56 µM. GABAA receptor agent 6 shows γ-GABAAR antagonist activity with low cellular membrane permeability.

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GABAA receptor agent 6 Chemical Structure

GABAA receptor agent 6 Chemical Structure

CAS No. : 1808463-81-1

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GABAA receptor agent 6 Related Antibodies

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Description

GABAA receptor agent 6 (compound 2027) is a potent γ-GABAAR antagonist with an Ki of 0.56 µM. GABAA receptor agent 6 shows γ-GABAAR antagonist activity with low cellular membrane permeability[1].

IC50 & Target

Ki: 0.56 µM (γ-GABAAR)[1]
In Vitro

GABAA receptor agent 6 (compound 2027) shows antagonist activity with IC50s of 6.68, 1.03, 0.36, 4.13, 4.96, 2.96, 0.29, 0.59 µM for α1β2δ, α4β1δ, α4β2δ, α6β2δ, α1β2γ2, α2β2γ2, α3β2γ2, α5β2γ2 subtypes, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GABAA receptor agent 6 Related Antibodies
Molecular Weight

315.41

Formula

C18H25N3O2
CAS No.
SMILES

O=C(C)NC1=CC=CC(C(N2CCC3(CC2)CCNCC3)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GABAA receptor agent 6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GABAA receptor agent 61808463-81-1GABAA receptor agent6GABAA receptor agent-6GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAA receptor agent 6 (compound 2027) shows antagonist activity with IC50s of 6.681.030.364.134.962.960.290.59 μM for α1β2δα4β1δα4β2δα6β2δα1β2γ2α2β2γ2α3β2γ2α5β2γ2 subtypesrespectively[1].Inhibitorinhibitorinhibit

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