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Cat. No.: HY-100518A

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T 26c sodium

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

T26c sodium is a potent and selective MMP13 inhibitor with IC₅₀ value of 6.9 pM. T26c sodium can inhibit the degradation of bovine nasal septal cartilage explants.

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CAS No.: 869298-22-6
Formule: C₂₄H₁₉N₃Na₂O₆S
Masse moléculaire:523.47

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

T 26c sodium Chemical Structure

CAS No.: 869298-22-6

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Description

T26c sodium is a potent and selective MMP13 inhibitor with IC₅₀ value of 6.9 pM. T26c sodium can inhibit the degradation of bovine nasal septal cartilage explants^[1].

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Chemical Information

CAS No. 869298-22-6
Masse moléculaire 523.47
Formule C₂₄H₁₉N₃Na₂O₆S
SMILES

O=C(NCC1=CC(OC)=CC=C1)C(N(C2=C3C(COCC4=CC=C(C(O[Na])=O)C=C4)=CS2)[Na])=NC3=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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Cell Stem Cell

Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal. [Abstract]

2023 May 4;30(5):648-664.e8. PMID: 37146584
Nat Commun

Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]

2026 Feb 12;17(1):1214. PMID: 41680175
Int J Biochem Cell Biol

MMP13 promotes the osteogenic potential of BMP9 by enhancing Wnt/β-catenin signaling via HIF-1α upregulation in mouse embryonic fibroblasts. [Abstract]

2023 Nov:164:106476. PMID: 37802385

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Nara H, et al. Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site. Bioorg Med Chem. 2014 Oct 1;22(19):5487-505. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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T 26c sodium

3 Cited Publications

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T 26c sodium

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Chemical Information

Publications (3)

Pureté et documentation

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T 26c sodium Related Classifications

HY-100518A Related Classifications