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Cat. No.: HY-122833

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FGFR3-IN-10

Name: FGFR3-IN-10
Brand: MedChemExpress
SKU: HY-122833
Price: 480.00 USD
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1 Cited Publications

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Based on 1 publication(s) in Google Scholar

FGFR3-IN-10 is a FGFR3 inhibitor with an IC₅₀ of <350 nM. FGFR3-IN-10 is applicable to research related to cancer, systemic sclerosis, fibrosis, achondroplasia, thanatophoric dysplasia, and Muenke syndrome.

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CAS No.: 2833703-74-3
Formule: C₂₃H₂₂ClFN₈O₂
Masse moléculaire:496.92

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FGFR3-IN-10 Chemical Structure

CAS No.: 2833703-74-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Pureté et documentation
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Activité biologique

Description

IC₅₀ & Target

^[1]

FGFR3

<350 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	0.93 μM Compound: 3	Inhibition of human full length TNIK in HEK293 cells co-transfected with full length SMAD1 incubated for 2 hrs by ELISA Inhibition of human full length TNIK in HEK293 cells co-transfected with full length SMAD1 incubated for 2 hrs by ELISA	[PMID: 31153805]

In Vitro

FGFR3-IN-10 (Example 46) inhibits the kinase activity of fibroblast growth factor receptor 3 (FGFR3) in FGFR3 enzyme inhibition assays, with an IC₅₀ < 350 nM.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 2833703-74-3
Masse moléculaire 496.92
Formule C₂₃H₂₂ClFN₈O₂
SMILES

OC[C@H](C1=CC=C(C=N1)F)OC2=CC(C3=C(N(C4CCN(CC4)C#N)N=N3)C)=CN5C2=C(Cl)C=N5
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Res Sq

2026 May 22.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Adedoyin David ABRAHAM, et al. Fgfr3 inhibitor compounds. World Intellectual Property Organization, WO2022187443A1 2022-09-09.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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FGFR3-IN-10

1 Cited Publications

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Pureté et documentation
Références

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FGFR3-IN-10

Publications Citing Use of MedChemExpress (MCE) FGFR3-IN-10