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z-

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By Research Areas:	Cancer (295) Cardiovascular Disease (46) Endocrinology (56) Infection (124) Inflammation/Immunology (128) Metabolic Disease (511) Neurological Disease (103)
Click Chemistry:	Labeling and Fluorescence Imaging (1) Azide (7) Alkynes (2)
Oligonucleotides:	Guanosine (1) Nucleoside Analogs (1) Rat Pre-designed siRNA Sets (1) Emulsifiers (1) Cationic Lipids (1) Mouse Pre-designed siRNA Sets (1) Phospholipids (15) Human Pre-designed siRNA Sets (4) Other Phosphoramidite (1) Phosphoramidites (1) Cholesterol (4) siRNAs (6)

1820

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

207

Peptides

Inhibitory Antibodies

254

Natural
Products

Recombinant Proteins

112

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101297

Z-IETD-FMK Maximum Cited Publications 68 Publications Verification Z-IE(OMe)TD(OMe)-FMK	Caspase	Cancer
Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor . Z-IETD-FMK is also a granzyme B inhibitor .

HY-16658

Z-VAD(OMe)-FMK 195+ Cited Publications Z-Val-Ala-Asp(OMe)-FMK	Caspase	Cancer
Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor . Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1 .

HY-164388

Z-VAD 15+ Cited Publications	Caspase Apoptosis Autophagy Necroptosis	Cardiovascular Disease Cancer
Z-VAD is an irreversible, broad-spectrum pan-caspase inhibitor that can inhibit a variety of caspases including caspase-3, -6, -7, -8, -9, etc. (with a weaker inhibitory effect on caspase-2). Z-VAD can block apoptosis signaling pathways, induce autophagy and necrosis in tumor cells, and has anti-angiogenic activity. Z-VAD can enhance the sensitivity of breast cancer and lung cancer cells to radiotherapy in vitro and in vivo, and prolong the growth delay of tumor xenograft models. Z-VAD is well tolerated and is mainly used in research related to cancer radiosensitization and cell death pathway regulation .

HY-128140

Z-FY-CHO 5+ Cited Publications Z-Phe-Tyr-CHO	Cathepsin	Neurological Disease Metabolic Disease
Z-FY-CHO (Z-Phe-Tyr-CHO) is a potent and specific cathepsin L (CTSL) inhibitor .

HY-P0019

Z-Gly-Gly-Arg-AMC 10+ Cited Publications	Fluorescent Dye Thrombin	Cardiovascular Disease
Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .

HY-P0109A

Z-FA-FMK 5+ Cited Publications (1S)-Z-FA-FMK	SARS-CoV Cathepsin Apoptosis Caspase	Infection Cancer
Z-FA-FMK ((1S)-Z-FA-FMK) is a potent Cathepsin B and L inhibitor. Z-FA-FMK blocks the induction of DEVDase activity, DNA fragmentation, and externalization of phosphatidylserine by selective synthetic retinoid-related molecules (RRMs). Z-FA-FMK inhibits apoptosis. Z-FA-FMK inhibits caspase activity and selectively inhibits recombinant effector caspases 2, -3, -6, and -7. Z-FA-FMK is a viral inhibitor. Z-FA-FMK inhibits reovirus replication in a susceptible host .

HY-123053

Z-Leu-Leu-Glu-AMC 3 Publications Verification Z-LLE-AMC	Proteasome	Neurological Disease
Z-Leu-Leu-Glu-AMC (Z-LLE-AMC) is a peptide-AMC linked substrate used to measure the postacidic-like hydrolysing activity of proteasome. Z-Leu-Leu-Glu-AMC can be used for the research of parkinson's disease .

HY-P1009

Z-YVAD-FMK 20+ Cited Publications	Caspase	Cancer
Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities .

HY-134434

Z-Arg-Arg-AMC hydrochloride 1 Publications Verification	Cathepsin Fluorescent Dye	Others
Z-Arg-Arg-AMC hydrochloride is a highly selective fluorescent Cathepsin B substrate. Z-Arg-Arg-AMC hydrochloride can be hydrolyzed by Cathepsin B to produce a fluorescent product for enzyme activity detection .

HY-P10004

Z-Ala-Ala-Asp-CMK 2 Publications Verification Z-AAD-CMK	Caspase Apoptosis Reactive Oxygen Species (ROS) Interleukin Related	Inflammation/Immunology Cancer
Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor. By binding to the active site of granzyme B, Z-Ala-Ala-Asp-CMK blocks its proteolytic function. Z-Ala-Ala-Asp-CMK has anti-inflammatory activity and can be used in the research of inflammatory diseases and cancer .

HY-160955

Z218484536	Phosphatase	Neurological Disease
Z218484536 is a selective and brain-penetrant phosphoserine phosphatase (PSPH) inhibitor. Z218484536 binds to PSPH with a K_d value of approximately 0.23 μM. Z218484536 reduces L-serine and D-serine levels in astrocytes. Z218484536 is able to suppress spontaneous epileptic seizures without causing serious side effects. Z218484536 also shows good anti-epileptic effects in the temporal lobe epilepsy (TLE) model .

HY-P0019A

Z-Gly-Gly-Arg-AMC acetate 10+ Cited Publications	Fluorescent Dye Thrombin	Others
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .

HY-178842

Z52	Ras ADC Payload	Cancer
Z52 is a Ras protein inhibitor. Z52 can be used for the research of cancer, such as pancreatic cancer .

HY-141867

Z-FF-FMK Z-Phe-Phe-FMK	Cathepsin MEK Caspase DNA/RNA Synthesis Apoptosis	Cardiovascular Disease Neurological Disease
Z-FF-FMK (Z-Phe-Phe-FMK) is a cell-permeable, irreversible, and cysteine protease inhibitor targeting cathepsin-L. Z-FF-FMK inhibits angiotensin II-induced MEK activation in vascular walls, aortic medial remodeling, blood pressure elevation, and upregulation of cystatin C in aortic walls. Z-FF-FMK prevents β-amyloid-mediated caspase-3 activation, poly (ADP-ribose) polymerase cleavage, DNA fragmentation, and apoptosis of cortical neurons (apoptosis). Z-FF-FMK can be used in research related to hypertension and Alzheimer's disease .

HY-10332

(Z)-Semaxanib 3 Publications Verification (Z)-SU5416	c-Met/HGFR	Cancer
(Z)-Semaxanib (compound (z)-1) is a potent tyrosine kinase inhibitor. (Z)-Semaxanib shows cytotoxicity for TAMH and HepG2 cells with IC₅₀s of 6.28 µM and 8.17 µM, respectively .

HY-N6794

10Z-Hymenialdisine (Z)-Hymenialdisine; Hymenialdisine	AMPK VEGFR PDGFR	Cancer
10Z-Hymenialdisine ((Z)-Hymenialdisine) is a natural bioactive pyrrole alkaloid. 10Z-Hymenialdisine is a pan kinase inhibitor, and has anticancer activities .

HY-P4217

Z-Gly-Pro-Arg-AMC hydrochloride 1 Publications Verification	Cathepsin	Others
Z-Gly-Pro-Arg-AMC hydrochloride a fluorescent trypsin and cathepsin K substrate. Z-Gly-Pro-Arg-AMC hydrochloride can be used to determine trypsin and cathepsin K activity .

HY-139507S

Z,Z-Dienestrol-d6	Isotope-Labeled Compounds	Others
Z,Z-Dienestrol-d₆ is the deuterium labeled Z,Z-Dienestrol .

HY-19123

Z-321	Prolyl Endopeptidase (PREP)	Neurological Disease
Z-321 is a prolylendopeptidase (PEP) inhibitor.

HY-172458

Z-3578 1 Publications Verification	Mas-related G-protein-coupled Receptor (MRGPR) TNF Receptor	Inflammation/Immunology
Z-3578 is an orally active small-molecule antagonist of MrgX2 with potent antipseudoallergic activity, exhibiting a K_D value of 729 nM. Z-3578 effectively inhibits mast cell degranulation induced by substance P (SP) and C48/80, suppresses the release of β-hexosaminidase, significantly reduces the release of histamine and TNF-α, and decreases intracellular calcium flux. In a mouse pseudoallergy model, Z-3578 significantly alleviates paw swelling and dye extravasation, and reduces serum histamine levels. Z-3578 can be used for the study of pseudoallergic reactions .

HY-178838

Z52-L16	Drug-Linker Conjugates for ADC Ras	Cancer
Z52-L16 is Drug-Linker Conjugates for ADC, which is composed of a linker and a Ras inhibitor Z52 (HY-178842). Z52-L16 can be used for the research of cancer, such as pancreatic cancer .

HY-129867

Z-Leu-Leu-Leu-AMC Z-LLL-AMC	Proteasome	Others
Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the 20S proteasome .

HY-P4500

Z-Arg-Arg-pNA	Cathepsin	Others
Z-Arg-Arg-pNA is a substrate for cathepsin B and can be used to detect this enzyme activity .

HY-134961

Z-Ala-Arg-Arg-AMC 1 Publications Verification Fluorogenic Proteasome Substrate; Z-ARR-AMC	Proteasome	Others
Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) is a fluorogenic substrate for assaying trypsin-like activity of proteasome .

HY-10517A

(Z)-Orantinib (Z)-SU6668; (Z)-TSU-68	VEGFR PDGFR FGFR	Cancer
(Z)-Orantinib ((Z)-SU6668) is a potent, selective, orally active and ATP competitive inhibitor of Flk‐1/KDR, PDGFRβ, and FGFR1, with IC₅₀s of 2.1, 0.008, and 1.2 µM, respectively. (Z)-Orantinib is a potent antiangiogenic and antitumor agent that induces regression of established tumors .

HY-120234

Z-LLNle-CHO Z-Leu-Leu-Nle-CHO; GSII	γ-secretase Proteasome Apoptosis	Cancer
Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia .

HY-P5975

Z-Leu-Leu-Leu-fluoromethyl ketone Z-LLL-FMK	Cathepsin SARS-CoV	Infection
Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge .

HY-134454

Z-Pro-Pro-CHO	Prolyl Endopeptidase (PREP) Parasite	Infection
Z-Pro-Pro-CHO is a potent inhibitor of prolyl oligopeptidase (POP), with extremely high affinity for human prolyl oligopeptidase (HsPOP) (IC₅₀=0.012 μM), and it also effectively inhibits the activity of Schistosoma mansoni prolyl oligopeptidase (SmPOP) (IC₅₀=0.16 μM). Z-Pro-Pro-CHO does not block the phosphorylation of ERK or the production of TNF-α or IFN-γ in immune cells from presensitized mice, nor does it induce harmful phenotypes in cultured Schistosoma mansoni schistosomula. Z-Pro-Pro-CHO only partially inhibits epithelial cell wound healing at extremely high concentrations. Z-Pro-Pro-CHO finds wide application in studies related to schistosomiasis .

HY-N0969

(Z)-Akuammidine 19-(Z)-Akuammidine; (Z)-Rhazine	Others	Others
(Z)-Akuammidine ((Z)-Rhazine) is isolated from Gelsemium elegans .

HY-W987949

Z-4105	Others	Neurological Disease
Z-4105 is an orally active nootropic agent. Z-4105 reverses the amnesic effects of electroconvulsive shock (ECS) and methylazoxymethanol acetate (MAM), and improves learning and memory functions. Z-4105 enhances the activity of the brain cholinergic system without affecting other neurotransmitter systems. Z-4105 significantly alleviates neuropathic pain in rats. Z-4105 can be used in the research of neuropathic pain and brain dysfunction .

HY-N0117AR

(Z)-Indirubin (Standard) (Z)-Couroupitine B (Standard); (Z)-Indigo red (Standard); (Z)-Indigopurpurin (Standard)	Reference Standards Apoptosis	Cancer
(Z)-Indirubin (Standard) is the analytical standard of (Z)-Indirubin (HY-N0117A). (Z)-Indirubin is an isomer of Indirubin (HY-N0117). Indirubin is a bisindole alkaloid with significant anticancer activity against chronic myeloid leukemia.

HY-N0336A

(Z)-3-Butylidenephthalide (Z)-Butylidenephthalide	Glycosidase	Metabolic Disease
(Z)-3-Butylidenephthalide is an antihyperglycemic agent by inhibiting the activity of intestinal and yeast R-glucosidases (IC₅₀=2.35 mM; K_i=4.86 mM) .

HY-178837

Z56	Ras ADC Payload	Cancer
Z56 is a Ras protein inhibitor. Z56 can be used for the research of cancer, such as pancreatic cancer .

HY-166114A

(Z)-Heptaprenyl-MPDA diammonium (Z)-Heptaprenyl phosphate diammonium	Bacterial	Infection
(Z)-Heptaprenyl-MPDA ((Z)-Heptaprenyl phosphate) diammonium is the (Z)-isomer of Heptaprenyl-MPDA (HY-166114). Heptaprenyl-MPDA (Heptaprenyl phosphate) is a short-chain homolog of undecaprenyl phosphate, is an endogenous substrate of Phospho-MurNAc-pentapeptide translocase (MraY). Heptaprenyl-MPDA can be used for bacterial infections research .

HY-137286

Z-Leu-Leu-Glu-βNA Z-Leu-Leu-Glu-β-naphthylamide	Proteasome	Others
Z-Leu-Leu-Glu-βNA (Z-Leu-Leu-Glu-β-naphthylamide) is a substrate for determination of the glutamylpeptidyl-peptide hydrolase activity of the 20S proteasome .

HY-P4295

Z-Phe-Ala-diazomethylketone PADK	Cathepsin γ-secretase	Neurological Disease
Z-Phe-Ala-diazomethylketone binds directly to Aβ42 monomers and small oligomers. Z-Phe-Ala-diazomethylketone inhibits the formation of Aβ42 dodecamers and inhibits Aβ42 fibril formation in the solution. Z-Phe-Ala-diazomethylketone has the potential for neurodegenerative disorders research .

HY-P4428

Z-Val-Lys-Met-AMC	Fluorescent Dye	Others
Z-Val-Lys-Met-AMC is a fluorescent substrate that can be used to detect the β-secretase activity of cathepsin B .

HY-W004853

Z-Glycinol N-Z-ethanolamine	PROTAC Linkers	Cancer
Z-Glycinol (N-Z-ethanolamine) is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-175753

Z17544625	Others	Cancer
Z17544625 is a Fascin inhibitor. Z17544625 has a strong binding capacity to fascin and inhibits Actin bundling. Z17544625 significantly reduces proliferation and impairs migration of CRC cells. Z17544625 can be used for cancer, especially colorectal cancer (CRC) research .

HY-P10322

Z-IETD-R110	Fluorescent Dye	Cancer
Z-IETD-R110 is a fluorescent substrate of caspases. Z-IETD-R110 acts as a substrate for caspase-8. When caspase-8 is activated, it can recognize and cut Z-IETD-R110, releasing fluorophore, which can be detected by fluorescence microscopy. Z-IETD-R110 can be used to study oxidative stress-induced apoptosis, particularly in pancreatic acinar cells .

HY-137521

Z-PDLDA-NHOH	MMP	Others
Z-PDLDA-NHOH is a potent and specific inhibitor of vertebrate collagenase .

HY-W011374

Z-Gly-Osu	Amino Acid Derivatives	Others
Z-Gly-Osu is a Glycine (HY-Y0966) derivative .

HY-P4369

Z-Arg-Arg-AMC	Cathepsin	Others
Z-Arg-Arg-AMC is a selective substrate of cathepsin B .

HY-P4428A

Z-Val-Lys-Met-AMC TFA	Fluorescent Dye	Others
Z-Val-Lys-Met-AMC TFA is a fluorescent substrate that can be used to detect the β-secretase activity of cathepsin B .

HY-114437

Fusion Inhibitory Peptide Z-D-Phe-Phe-Gly-OH; FIP; Virus Replication Inhibitory Peptide	Influenza Virus	Infection
Fusion Inhibitory Peptide (Z-D-Phe-Phe-Gly-OH, FIP, Virus Replication Inhibitory Peptide) is a potent inhibitor of the virus replication, by inhibiting the membrane fusing activity of a viral glycoprotein .

HY-404230

Z52/Z56 intermediate	Ras	Others
Z52/Z56 intermediate is a key intermediate in the synthesis of RAS inhibitors .

HY-W008981

Z-Lys(Z)-OH	Amino Acid Derivatives	Others
Z-Lys(Z)-OH is a lysine derivative .

HY-W008487

Z-Arg(Z)2-OH	Amino Acid Derivatives	Others
Z-Arg(Z)2-OH is an arginine derivative .

HY-138096

Z-LLF-CHO Z-Leu-Leu-Phe-CHO	Proteasome	Cancer
Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) is a potent inhibitor of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (K_i = 460 nM). Z-LLF-CHO is also a NF-κB nuclear translocation inhibitor .

HY-P10001

Z-IETD-pNA Z-Ile-Glu-Thr-Asp-pNA	Caspase	Cancer
Z-IETD-pNA (Z-Ile-Glu-Thr-Asp-pNA) is a colorimetric caspase-8 and granzyme B substrate. Z-IETD-pNA is hydrlyzed by caspase 8 to generate pNA .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0401A

(Z)-Ligustilide 5 Publications Verification	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Dicerothamnus rhinocerotis Umbelliferae Plants Disease Research Fields Source Classification	Bacterial Estrogen Receptor/ERR FATP
(Z)-Ligustilide is extracted from Ligusticum chuanxiong Hort, has antimicrobial and antifungal activity, exhibits an average antifungal score of 5.6 . (Z)-Ligustilide is orally active, it inhibits the expression of FATP5 and DGAT, inhibits fatty acid uptake and esterification in mice and has potential as therapeutics for nonalcoholic fatty liver disease (NAFLD) . (Z)-Ligustilide is also able to reactivate ERα, has epigenetic regulation, and is used in the study of tamoxifen-resistant breast cancer .

HY-107738

Guggulsterone 20+ Cited Publications Z/E-Guggulsterone	Triterpenes Structural Classification Classification of Application Fields Terpenoids Plants Burseraceae Disease Research Fields Commiphora wightii Cancer	Apoptosis JNK Akt Caspase FXR Autophagy
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt . Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC₅₀s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively .

HY-110066

(Z)-Guggulsterone 5+ Cited Publications	Classification of Application Fields Commiphora myrrha (Nees) Engl. Plants Burseraceae Disease Research Fields Steroids Source Classification Cancer	Apoptosis VEGFR Akt Angiotensin-converting Enzyme (ACE) SARS-CoV FXR
(Z)-Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis . (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection .

HY-W016814

(Z)-Aconitic acid 1 Publications Verification cis-Aconitic acid	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Amino Acid Decarboxylase
(Z)-Aconitic acid is an orally active glutamate decarboxylase inhibitor. (Z)-Aconitic acid reduces IκB-α phosphorylation. (Z)-Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A)-induced gout .

HY-W011688

Methyl palmitoleate 1 Publications Verification (Z)-Methyl hexadec-9-enoate; Methyl cis-9-Hexadecenoate	Structural Classification other families Classification of Application Fields Other Diseases Plants Disease Research Fields Lipid Source Classification	Drug Isomer
Methyl palmitoleate ((Z)-Methyl hexadec-9-enoate), a fatty acid methyl ester, is an analogue of Palmitoleate with cytoprotective and growth-promoting properties .

HY-W010607

cis-3-Hexen-1-ol (Z)-3-Hexen-1-ol	Structural Classification Natural Products Neurological Disease Classification of Application Fields Leguminosae Plants Phaseolus vulgaris Linn. Disease Research Fields Source Classification Food Research	Environmental Pollutants
cis-3-Hexen-1-ol ((Z)-3-Hexen-1-ol) is a green grassy smelling compound found in many fresh fruits and vegetables with bitter taste enhancement. cis-3-Hexen-1-ol is widely used as an added flavor in processed food to provide a fresh green quality. cis-3-Hexen-1-ol is an attractant to various insects .

HY-113463

Cholesteryl eicosapentaenoate CE(20:5(5Z,8Z,11Z,14Z,17Z)	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite COX
Cholesteryl eicosapentaenoate (CE(20:5(5Z,8Z,11Z,14Z,17Z)), a cholesteryl ester, is a COX-1 and COX-2 inhibitor with IC₅₀ values of 14.6 μg/mL and 17.3 μg/mL, respectively. Cholesteryl eicosapentaenoate shows strong anti-inflammatory and antioxidant activities .

HY-114610

13Z,16Z-Docosadienoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Free Fatty Acid Receptor Bacterial
13Z,16Z-Docosadienoic acid is a GPR120 agonist with bactericidal activity. 13Z,16Z-Docosadienoic acid serves as a potential biomarker for canine mammary tumors. 13Z,16Z-Docosadienoic acid is used in the research of bacterial infections, Lyme disease, Graves' disease and mammary tumors .

HY-113037

(E/Z)-Farnesyl pyrophosphate (E/Z)-Farnesyl diphosphate	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	TRP Channel Endogenous Metabolite
(E/Z)-Farnesyl pyrophosphate ((E/Z)-Farnesyl diphosphate), a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. (E/Z)-Farnesyl pyrophosphate is a TRPM2 (TRP Channel) agonist, activates TRPM2 opening for ion influx. (E/Z)-Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis .

HY-13212

(Z)-2-Decenoic acid cis-2-Decenoic acid	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification Cancer	Bacterial
(Z)-2-decenoic acid (cis-2-Decenoic acid) is an unsaturated fatty acid produced by Pseudomonas aeruginosa. (Z)-2-decenoic acid induces a dispersion response in biofilms formed by a range of gram-negative bacteria, including P. aeruginosa, and by gram-positive bacteria. (Z)-2-decenoic acid inhibits biofilm development .

HY-113120

Stearidonic acid 6Z,9Z,12Z,15Z-Octadecatetraenoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Lipoxygenase
Stearidonic acid (6Z,9Z,12Z,15Z-Octadecatetraenoic acid) is an orally active polyunsaturated fatty acid found in blackcurrant seed oil. Stearidonic acid can inhibit 5-lipoxygenase and reduce leukotriene and 5-HETE synthesis. Stearidonic acid can increase the content of eicosapentaenoic acid (EPA) in red blood cells. Stearidonic acid can be used for the research of metabolic disease .

HY-N6794

10Z-Hymenialdisine (Z)-Hymenialdisine; Hymenialdisine	Alkaloids Pyrrole Alkaloids Animals Classification of Application Fields Marine natural products Sponge Disease Research Fields Biological Pesticide Research Source Classification Cancer Agricultural Research	AMPK VEGFR PDGFR
10Z-Hymenialdisine ((Z)-Hymenialdisine) is a natural bioactive pyrrole alkaloid. 10Z-Hymenialdisine is a pan kinase inhibitor, and has anticancer activities .

HY-128750

(Z)-4-Amino-4-oxobut-2-enoic acid	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
(Z)-4-Amino-4-oxobut-2-enoic acid is an endogenous metabolite.

HY-121999

(+)-cis-Abienol (Z)-Abienol	Nicotiana tabacum L. Terpenoids Diterpenoids Plants Solanaceae Source Classification	Bacterial
(+)-cis-Abienol (Compound Z-abienol), a diterpenoid, can be isolated from leaves of tobacco. (+)-cis-Abienol inhibits hyphal growth of P. nicotianae .

HY-108398B

11(Z),14(Z),17(Z)-Eicosatrienoic acid	Microorganisms Ketones, Aldehydes, Acids Source Classification	Endogenous Metabolite
11(Z),14(Z),17(Z)-Eicosatrienoic acid is an unsaturated fatty acid that can maintain the continued replication of functional mitochondria in Saccharomyces cerevisiae (KD115) .

HY-W742821

(Z)-11-Octadecenal	Natural Products Animals Source Classification	Sex Pheromone
(Z)-11-Octadecenal is a female pheromone with diurnal stability, isolated from the pheromone glands of female rice leaffolder moths .

HY-N0969

(Z)-Akuammidine 19-(Z)-Akuammidine; (Z)-Rhazine	Natural Products Classification of Application Fields Other Diseases Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Disease Research Fields Source Classification	Others
(Z)-Akuammidine ((Z)-Rhazine) is isolated from Gelsemium elegans .

HY-N0336A

(Z)-3-Butylidenephthalide (Z)-Butylidenephthalide	Natural Products Classification of Application Fields Metabolic Disease Umbelliferae Plants Aster scaber Thunb. Disease Research Fields Source Classification	Glycosidase
(Z)-3-Butylidenephthalide is an antihyperglycemic agent by inhibiting the activity of intestinal and yeast R-glucosidases (IC₅₀=2.35 mM; K_i=4.86 mM) .

HY-W016814R

(Z)-Aconitic acid (Standard) cis-Aconitic acid (Standard)	Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
(Z)-Aconitic acid (Standard) is the analytical standard of (Z)-Aconitic acid. This product is intended for research and analytical applications. (Z)-Aconitic acid is a glutamate decarboxylase inhibitor. (Z)-Aconitic acid reduces IκB-α phosphorylation. (Z)-Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A)-induced gout .

HY-N10840

Furanogermacra-1(10)Z,4Z-dien-6-one	Commiphora myrrha (Nees) Engl. Terpenoids Sesquiterpenes Plants Burseraceae Source Classification	Others
Furanogermacra-1(10)Z,4Z-dien-6-one is a furanosesquiterpenoid that can be found in Commiphora myrrha .

HY-W336192

(3E,8Z,11Z)-3,8,11-Tetradecatrienyl acetate	Structural Classification Natural Products Animals Source Classification	Environmental Pollutants Endogenous Metabolite
(3E,8Z,11Z)-3,8,11-Tetradecatrienyl acetate is a sex pheromone capable of attracting male South American tomato pinworms (Scrobipalpuloides absoluta), which can be isolated from the tomato pest .

HY-N11031

Z-Antiepilepsirine	Alkaloids Piperidine Alkaloids Piper capense Piperaceae Plants Source Classification	Parasite
Z-Antiepilepsirine is an amide alkaloid that can be found in Piper capense L.f. Z-Antiepilepsirine shows antiplasmodial activity with an IC₅₀ value of 27 µM for W2 strain of Plasmodium falciparum .

HY-W009165R

(Z)-9-Tricosene (Standard) cis-9-Tricosene (Standard)	Structural Classification Natural Products Animals Source Classification	Insecticide Reference Standards
(Z)-9-Tricosene (Standard) is the analytical standard of (Z)-9-Tricosene. This product is intended for research and analytical applications. (Z)-9-Tricosene (cis-9-Tricosene) is an insect pheromone present in flies of the order Diptera (such as the housefly) and can be used as an insecticide[1].

HY-N10814

(Z)-2-Angeloyloxymethyl-2-butenoic	Ketones, Aldehydes, Acids Centaurea ornata Plants Umbelliferae Source Classification	Others
(Z)-2-Angeloyloxymethyl-2-butenoic is a natural product that can be found in the roots of Anthriscus sylvestris Hoffm.

HY-W780803

(Z,E)-9,12-Tetradecadienol	Natural Products Animals Source Classification	Parasite
(Z,E)-9,12-Tetradecadienol is a synthetic enhancer of male Ephestia cautella attraction .

HY-W751418

N-Nervonoyl taurine (Z)-2-tetracos-15-enamidoethanesulfonic acid	Natural Products Endogenous metabolite Source Classification	FAAH
N-Nervonoyl taurine ((Z)-2-tetracos-15-enamidoethanesulfonic acid) is a fatty acid-taurine conjugate derived from nervonic acid. N-Nervonoyl taurine is a substrate of fatty acid amide hydrolase (FAAH) discovered during metabolite profiling .

HY-W010607R

cis-3-Hexen-1-ol (Standard) (Z)-3-Hexen-1-ol (Standard)	Structural Classification Natural Products Microorganisms Leguminosae Plants Phaseolus vulgaris Linn. Source Classification	Reference Standards Others
cis-3-Hexen-1-ol (Standard) is the analytical standard of cis-3-Hexen-1-ol. This product is intended for research and analytical applications. cis-3-Hexen-1-ol ((Z)-3-Hexen-1-ol) is a green grassy smelling compound found in many fresh fruits and vegetables. cis-3-Hexen-1-ol is widely used as an added flavor in processed food to provide a fresh green quality. cis-3-Hexen-1-ol is an attractant to various insects .

HY-N1214A

(E/Z)-Squalene (E/Z)-Super Squalene; (E/Z)-AddaVax	Triterpenes Structural Classification Animals Terpenoids Source Classification	Apoptosis
(E/Z)-Squalene ((E/Z)-Super Squalene; (E/Z)-AddaVax) is a triterpenic compound. (E/Z)-Squalene accumulates and reduces liver cholesterol and triglycerides in the liver. (E/Z)-Squalen regulates the production of intracellular active oxidants (ROS) and induces apoptosis and necrosis in a concentration-and time-dependent manner .

HY-110066R

(Z)-Guggulsterone (Standard)	Commiphora myrrha (Nees) Engl. Plants Burseraceae Steroids Source Classification	Reference Standards Apoptosis VEGFR Akt Angiotensin-converting Enzyme (ACE) SARS-CoV FXR
(Z)-Guggulsterone (Standard) is the analytical standard of (Z)-Guggulsterone. This product is intended for research and analytical applications. (Z)-Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis . (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection .

HY-W745644

(Z)-7-Hexadecenal	Natural Products Animals Source Classification	Parasite
(Z)-7-Hexadecenal is a sex pheromone that attracts male insects, isolated from female Heliothis virescens moths .

HY-N12880

(10Z,12E)-10,12-Hexadecadien-1-ol Z10,E12-16:OH	Structural Classification Natural Products Animals Source Classification	Others
(10Z,12E)-10,12-Hexadecadien-1-ol (Z10,E12-16:OH) is a microlepidopteran attractant isolated from female scent glands .

HY-N11637A

(Z)-Ganoderenic acid K	Triterpenes Microorganisms Terpenoids Source Classification	HMG-CoA Reductase (HMGCR)
(Z)-Ganoderenic acid K is a triterpene acid that can be isolated from the basidiocarp of Ganoderma lucidum. Ganoderenic acid K (HY-N11637), the isomer of (Z)-Ganoderenic acid K, is a HMG-CoA reductase (HMGCR) inhibitor with an IC₅₀ of 16.5 μM .

HY-W009165

(Z)-9-Tricosene cis-9-Tricosene	Structural Classification Natural Products Animals Source Classification	Environmental Pollutants Insecticide
(Z)-9-Tricosene (cis-9-Tricosene) is an insect pheromone present in flies of the order Diptera (such as the housefly) and can be used as an insecticide .

HY-N2099A

(Z)-Onjisaponin B (Z)-Senegin III	Triterpenes Structural Classification Polygala senega L. Terpenoids Polygalaceae Plants Pentacyclic Triterpenoids Source Classification	Drug Derivative
(Z)-Onjisaponin B ((Z)-Senegin III) is a derivative of Onjisaponin B (HY-N2099). Onjisaponin B is an orally active natural product derived from Polygala tenuifolia. Onjisaponin B inhibits NF-κB p65. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin. Onjisaponin B reduces β-amyloid (Aβ) production. Onjisaponin B reduces radiation-induced cell apoptosis. Onjisaponin B has anti-oxidant and anti-inflammatory activities. Onjisaponin B can be used for neurological disease and radiation injury study, and its metabolite tenuifolin (TF) can enter the brain through the BBB .

HY-107738R

Guggulsterone (Standard) Z/E-Guggulsterone (Standard)	Triterpenes Structural Classification Terpenoids Plants Burseraceae Commiphora wightii	Apoptosis JNK Akt Caspase FXR Autophagy Reference Standards
Guggulsterone (Standard) is the analytical standard of Guggulsterone (HY-107738). This product is intended for research and analytical applications. Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC₅₀s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively.

HY-N11163

(Z)-(1R,3R,4R,4aS,8R,8aR)-3,4,8,8a-Tetramethyl-7-oxo-4-(2-(5-oxo-2,5-dihydrofuran-3-yl)ethyl)decahydronaphthalen-1-yl 2-methylbut-2-enoate	Terpenoids Diterpenoids Plants Compositae Glycyrrhiza lepidota Pursh Source Classification	Others
(Z)-(1R,3R,4R,4aS,8R,8aR)-3,4,8,8a-Tetramethyl-7-oxo-4-(2-(5-oxo-2,5-dihydrofuran-3-yl)ethyl)decahydronaphthalen-1-yl 2-methylbut-2-enoate (compound 7a) is a clerodane diterpene .

HY-138050

Nyasol (-)-Nyasol; (Z)-Hinokiresinol; cis-Hinokiresinol	Phenols Polyphenols Hypoxis angustifolia Lam. Plants Source Classification Asparagaceae Juss.	NO Synthase Bacterial Fungal Parasite Leukotriene Receptor
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells .

HY-N7702

N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide 1 Publications Verification	Natural Products other families Classification of Application Fields Metabolic Disease Plants Disease Research Fields Source Classification	Wnt β-catenin
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide is a macamide isolated from Maca (Lepidium meyenii Walp.) N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide induces mesenchymal stem cells osteogenic differentiation and consequent bone formation through activating the canonical Wnt/β‐catenin signaling pathway. N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide can be used for the research of osteoporosis .

HY-N12259

4(Z),7(Z)-Decadienoic acid	Ketones, Aldehydes, Acids Mangifera indica Linn. Plants Anacardiaceae Source Classification	Endogenous Metabolite
4(Z),7(Z)-Decadienoic acid is a fatty acid, which is a component of cloacal gland secretion of the tuatara (Sphenodon punctatus) .

HY-W230975

(E/Z)-Piperine (E/Z)-Bioperine; (E/Z)-1-Piperoylpiperidine	Alkaloids Piperidine Alkaloids Piperaceae Plants Piper nigrum Linn. Source Classification	Cytochrome P450 P-glycoprotein
(E/Z)-Piperine ((E/Z)-Bioperine) is an alkaloid with a pungent property. (E/Z)-Piperine shows anti-inflammation, immunomodulatory and anti-cancer, antispasmodic and anti-secretory effects. (E/Z)-Piperine demonstrates significant neuroprotective effect in Alzheimer’s disease and Parkinson’s disease .

HY-N12920

(Z)-3-Dodecenyl acetate Z3-12:Ac	Natural Products Animals Source Classification	Others
(Z)-3-Dodecenyl acetate (Z3-12:Ac) is a specific sex pheromone attracting females, isolated from pentane extracts of mature unmated male yellow mealworm beetles .

HY-W747088

(2Z,13Z)-Octadecadienyl acetate	Natural Products Animals Source Classification	Sex Pheromone
(2Z,13Z)-Octadecadienyl acetate is a female pheromone that attracts male clearwing moths and disrupts mating, isolated from Japanese persimmon clearwing moths (Synanthedon tenuis (Lepidoptera: Sesiidae)) .

HY-59097

(E/Z)-Tapinarof (E/Z)-WBI-1001; (E/Z)-Benvitimod; (E/Z)-GSK2894512	Microorganisms Antibiotics Phenols Polyphenols Source Classification	Antibiotic Bacterial Fungal
(E/Z)-Tapinarof ((E/Z)-WBI-1001; 3,5-dihydroxy-4-isopropylstilbene) is a broad-spectrum antibiotic. (E/Z)-Tapinarof has anti-bacterial, anti-fungal and anti-nematode activities .

HY-13225E

(E/Z)-Rivanicline (E/Z)-RJR-2403; (E/Z)-Metanicotine	Alkaloids Duboisia hopwoodii (F.Muell.) F.Muell. Quinoline Alkaloids Solanaceae Plants Source Classification	nAChR
(E/Z)-Rivanicline ((E/Z)-RJR-2403, (E/Z)-Metanicotine) is the E/Z mixture of Rivanicline (HY-13225A). Rivanicline is a neuronal nicotinic receptor (neuronal nicotinic receptor) agonist that is highly selective for the α4β2 subtype, K_i is 26 nM, which is more than 1000 times more inhibitory than α7 receptor .

HY-W140227

(Z,Z)-4,7-Decadienol	Natural Products Araceae Acorus calamus L. Plants Source Classification	Others
(Z,Z)-4,7-Decadienol is a volatile component of acorus oil essential oil and an uncommon fragrance in orchids .

HY-N12885

(11Z,13E)-Hexadecadienal	Natural Products Animals Source Classification	Others
(11Z,13E)-Hexadecadienal is a synthetic isomer of the hexane extract of the unmated female or female pheromone glands that can attract male Amyelois transitella (Walker) (Lepidoptera: Pyralidae) when mixed with (11Z,13Z)-hexadecadien-1-ol, (11Z,13E)-hexadecadien-1-ol, (3Z,6Z,9Z,12Z,15Z)-tricosapentaene (C23 pentaene) .

HY-N12894

(Z,E)-7,11-Hexadecadienyl acetate (7Z,11E)-Gossyplure; (Z7,E11-16:Ac)	Natural Products Animals Source Classification	Others
(Z,E)-7,11-Hexadecadienyl acetate ((7Z,11E)-Gossyplure; (Z7,E11-16:Ac)) is a synthetic female sex pheromone effective in attracting Cadra cautella, Pectinophoragossypiella, and Spodoptera exigua .

HY-134211

(Z)-2-Octenoic acid	Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Z-2-Octenoic acid is the Z-isomer of 2-Octenoic acid. trans-2-Octenoic acid is a metabolite of Mucor species.

HY-N12058

(Z)-9-Nonadecene	Natural Products Animals Source Classification	Others
(Z)-9-Nonadecene is the anal secretion of a species of thrips .

HY-W108415

Z12-Tetradecenyl acetate	Natural Products Animals Source Classification	Others
Z12-Tetradecenyl acetate is a pheromone produced by Ostrinia nubilalis .

Cat. No.	Product Name	Chemical Structure

HY-139507S

Z,Z-Dienestrol-d6
Z,Z-Dienestrol-d₆ is the deuterium labeled Z,Z-Dienestrol .

HY-132477S

(Z)-4-Hydroxy Tamoxifen-d5
(Z)-4-Hydroxy Tamoxifen-d₅ is the deuterium labeled (Z)-4-Hydroxy Tamoxifen .

HY-N0117AS

(Z)-Indirubin-d4
(Z)-Indirubin-d₄ is the deuterium labeled (Z)-Indirubin .

HY-13757AS

Tamoxifen-d5
Tamoxifen-d₅ is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity .

HY-170007S

5(Z),8(Z)-Tetradecadienoic Acid-d11
5(Z),8(Z)-Tetradecadienoic Acid-d₁₁ is deuterium labeled 5(Z),8(Z)-Tetradecadienoic Acid .

HY-18719S

Endoxifen-d5 (Z-isomer)
Endoxifen-d₅ (Z-isomer) is the deuterium labeled Endoxifen (Z-isomer) (HY-18719). Endoxifen (Z-isomer) is an oral active Tamoxifen (HY-13757A) metabolite, inducing an anti-estrogenic effect in breast cancer cells expressing ERα. Endoxifen (Z-isomer) inhibits hERG. This effect is concentration-dependent, with an IC₅₀ value of 1.6 μM .

HY-16950BS

(E)-4-Hydroxytamoxifen-d5
(E)-4-Hydroxytamoxifen-d5 ((E)-Afimoxifene-d5) is the deuterium labeled (E)-4-Hydroxytamoxifen. (E)-4-Hydroxytamoxifen ((E)-Afimoxifene), the less active isomer of (Z)-4-hydroxytamoxifen, is an estrogen receptor modulator.

HY-118861AS1

Clomiphene-d5 citrate
Clomiphene-d₅ (citrate) is the deuterium labeled Enclomiphene citrate. Enclomiphene citrate is a potent and orally active oestrogen receptor antagonist, with antioestrogenic property .

HY-A0287S

Clomiphene-d5 hydrochloride

Clomifene (Clomifene; (Z/E)-Enclomiphene; (Z/E)-Enclomifene)-d₅ hydrochloride is a deuterium labeled Clomifene hydrochloride (HY-A0287A). Clomiphene hydrochloride is an orally active ovulation-inducing agent. Clomiphene hydrochloride binds to hypothalamic estrogen receptors to elevate FSH levels, and exhibits antiestrogenic or estrogenic properties. Clomiphene hydrochloride can induce erturbations during meiotic maturation and cytogenetic abnormalities in mouse oocytes. Clomiphene hydrochloride ameliorates memory impairment in PCOS models. Clomiphene hydrochloride mobilizes cytosolic calcium and reduces viability in prostate cancer cells. Clomiphene hydrochloride can be used for the research of polycystic ovary syndrome (PCOS) and prostate cancer .

HY-117057S

Hexaenoic acid-d6

Hexaenoic acid-d₆ is deuterium labeled Hexaenoic acid. Very long chain polyunsaturated fatty acids (VLCPUFAs) are important components of ceramides and sphingomyelin and are present in retina, sperm, and brain. Tetratriaconta-16(Z),19(Z),22(Z),25(Z),28(Z),31(Z)-hexaenoic acid is a C34:6 VLCPUFA whose specific biological actions are largely unknown. This VLCPUFA, along with others, has been investigated for its role in activating protein kinase C .

HY-16561S2

(E/Z)-Resveratrol-13C6
Resveratrol-(4-Hydroxyphenyl)- ¹³CN₆ is the ¹³C labeled Resveratrol-(4-Hydroxyphenyl) .

HY-15306S

Eltrombopag-13C4

1 Publications Verification

Eltrombopag- ¹³C₄ (SB-497115- ¹³C₄) is ^{13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells .}

HY-163164S

18:1-17:1-18:1 TG-d5
18:1-17:1-18:1 TG-d5, 1,3-dioleoyl-2-heptadec-10Z-enoyl-glycerol-d5, is a deuterated substance .

HY-W704878

(Z)-Entacapone-d10-1
(Z)-Entacapone-d₁₀-1 is the deuterium labeled (Z)-Entacapone (HY-139089). (Z)-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor Entacapone (HY-14280). It is also a potential impurity found in commercial preparations of Entacapone and a degradant of Entacapone formed by UV light exposure.

HY-W654395

Methyl jasmonate-d5 (mixture of diastereomers)
Methyl jasmonate-d₅ (mixture of diastereomers) is deuterium labeled Methyl (Z)-2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate .

HY-120546S

Ulixacaltamide-d9 hydrochloride
Ulixacaltamide-d₉ (hydrochloride) salt is the deuterium labeled Ulixacaltamide hydrochloride .

HY-13757S

Tamoxifen-d3 hydrochloride

Tamoxifen-d₃ hydrochloride is deuterated labeled Tamoxifen (Citrate) (HY-13757). Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells .Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively . Tamoxifen Citrate activates autophagy and induces apoptosis .Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse .

HY-145003S

4(Z),7(Z)-Decadienoic acid-d5
4(Z),7(Z)-Decadienoic acid-d₅ is the deuterium labeled 4(Z),7(Z)-Decadienoic acid .

HY-152023S

(7Z,10Z,13Z)-7,10,13-Hexadecatrienoic-7,8,10,11,13,14-d6 acid
(7Z,10Z,13Z)-7,10,13-Hexadecatrienoic-7,8,10,11,13,14-d₆ acid is deuterium labeled (7Z,10Z,13Z)-Hexadeca-7,10,13-trienoic acid .

HY-W744888

(Z,Z)-5,11-Eicosadienoic Acid Methyl Ester-d3
(Z,Z)-5,11-Eicosadienoic Acid Methyl Ester-d₃ is the deuterium labeled (Z,Z)-5,11-Eicosadienoic Acid Methyl Ester.

HY-100646AS

(Z)-10-Hydroxynortriptyline-d3
(Z)-10-Hydroxynortriptyline-d₃ is the deuterium labeled (Z)-10-Hydroxynortriptyline (HY-100646A). (Z)-10-Hydroxynortriptyline is a metabolite of Nortriptyline (HY-118620). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression .

HY-W770278

Bisphenol Z-13C12
Bisphenol Z-13C12 is the ¹³C labeled isotope of Bisphenol Z-13C12 (HY-W770278) .

HY-139089S

(Z)-Entacapone-d10
(Z)-Entacapone-d₁₀ is the deuterium labeled (Z)-Entacapone .

HY-N0117AS1

(Z)-Indirubin-d8
(Z)-Indirubin-d₈ is the deuterium labeled (Z)-Indirubin .

HY-N0401AS

(Z)-Ligustilide-d7
(Z)-Ligustilide-d₇ is the deuterium-labeled (Z)-Ligustilide (HY-N0401A) .

HY-B0274CS

(E/Z)-Chlorprothixene-d6 hydrochloride
(E/Z)-Chlorprothixene-d₆ hydrochloride is the deuterium labeled (E/Z)-Chlorprothixene hydrochloride .

HY-B1808S

(E/Z)-Triprolidine-d8 hydrochloride
(E/Z)-Triprolidine-d₈ (hydrochloride) is the deuterium labeled (E/Z)-Triprolidine hydrochloride .

HY-10448S

(E/Z)-Capsaicin-d3
(E/Z)-Capsaicin-d₃ is the deuterium labeled (E/Z)-Capsaicin[1].

HY-W750888

(Z)-Chlorolefin-13C6
(Z)-Chlorolefin- ¹³C₆ is the ¹³C-labeled (Z)-Chlorolefin- ¹³C₆.

HY-W654197

(E/Z)-Flupentixol dihydrochloride-d4
(E/Z)-Flupentixol dihydrochloride-d₄ is the deuterium labeled (E/Z)-Flupentixol dihydrochloride.

HY-W007750S

H-Lys(Z)-OH-d3
H-Lys(Z)-OH-d₃ is the deuterium labeled H-Lys(Z)-OH.

HY-143676S

(1E,4Z,6E)-Curcumin-d6
(1E,4Z,6E)-Curcumin-d₆ is the deuterium labeled (1E,4Z,6E)-Curcumin .

HY-B0426AS1

(Z)-Olopatadine-d3 hydrochloride
(Z)-Olopatadine-d₃ (hydrochloride) is deuterium labeled Olopatadine (hydrochloride).

HY-132500S

(E/Z)-4-Hydroxy Toremifene-d6
(E/Z)-4-Hydroxy Toremifene-d₆ is the deuterium labeled (E/Z)-4-Hydroxy Toremifene .

HY-150533S

(E/Z)-Mycophenolic Acid-13C,d3
(E/Z)-Mycophenolic Acid- ¹³C,d₃ is the deuterium and ¹³C labeled (E/Z)-Mycophenolic Acid .

HY-156260S

Gamma-6Z-Dodecenolactone-d2
Gamma-6Z-Dodecenolactone-d₂ is deuterated labeled Gamma-6Z-Dodecenolactone.

HY-146919S

(4E,14Z)-Sphingadiene-d7
4E,14Z-Sphingadiene-d₇ is deuterium labeled 4E,14Z-Sphingadiene.

HY-W099645S

Methyl-d3 (Z)-docos-13-enoate
Methyl-d₃ (Z)-docos-13-enoate is the deuterium labeled (Z)-Methyl docos-13-enoate (HY-W099645). (Z)-Methyl docos-13-enoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W013326S

Bisphenol Z-d6
Bisphenol Z-d₆ is the deuterium labeled 4,4'-(Cyclohexane-1,1-diyl)diphenol (HY-W013326) .

HY-132647S

N-Desmethyl-4’-hydroxy Tamoxifen-d3 (E/Z Mixture)
N-Desmethyl-4’-hydroxy Tamoxifen-d₃ (E/Z Mixture) is the deuterium labeled N-Desmethyl-4’-hydroxy Tamoxifen (E/Z Mixture) .

HY-115705S

1,2,3-Tri-10(Z)-Heptadecenoyl Glycerol-d5
1,2,3-Tri-10(Z)-Heptadecenoyl Glycerol-d₅ is the deuterium labeled 1,2,3-Tri-10(Z)-Heptadecenoyl Glycerol .

HY-156326S1

(3E,5Z)-Octadien-2-one-13C2
(3E,5Z)-Octadien-2-one- ¹³C₂ is ¹³C labeled (3E,5Z)-Octadien-2-one.

HY-W392083S1

(1,3E,5Z)-Undeca-1,3,5-triene-d5
(1,3E,5Z)-Undeca-1,3,5-triene-d₅ is deuterated labeled (1,3E,5Z)-Undeca-1,3,5-triene.

HY-126199S

(Z)-Tetrachlorvinphos-d6
(Z)-Tetrachlorvinphos-d₆ is the deuterium labeled Tetrachlorvinphos (HY-126199). Tetrachlorvinphos is an organophosphorus pesticide that has the activity of inhibiting cholinesterase. Tetrachlorvinphos is used as a pesticide, mainly for the control of pests. Tetrachlorvinphos has low toxicity to mammals .

HY-115705

1,2,3-Tri-10(Z)-heptadecenoyl glycerol
1,2,3-Tri-10(Z)-heptadecenoyl glycerol (TG(17:1/17:1/17:1)) is a biochemical assay reagent, which can be used as an internal standard for the quantification of biological triglyceride .

HY-158947S

1-1(Z)-Hexadecenyl-2-Palmitoyl-d9-sn-glycero-3-PE
1-1(Z)-Hexadecenyl-2-Palmitoyl-d₉-sn-glycero-3-PE is deuterium labeled 1-1(Z)-Hexadecenyl-2-palmitoyl-sn-glycero-3-PE .

HY-W705777

2-Chloropropane-1,3-diyl dioleate
2-Chloropropane-1,3-diyl dioleate (1,1′-(2-Chloro-1,3-propanediyl) di-(9Z)-9-octadecenoate) is an ester product.

HY-165678S

(±)-10-Hydroxy-12(Z)-Octadecenoic acid-d5
(±)-10-Hydroxy-12(Z)-Octadecenoic acid-d₅ (10-Hydoxy-cis-12-Octadeceoic Acid-d₅) is deuterium labeled (±)-10-Hydroxy-12(Z)-Octadecenoic acid .

HY-W704752

Z-Doxepin-d3 Hydrochloride

Z-Doxepin-d₃ hydrochloride is the deuterium labeled 7-Hydroxychlorpromazine hydrochloride (HY-W704749). 7-Hydroxychlorpromazine hydrochloride is the active metabolite of Chlorpromazine (HY-12708). 7-Hydroxychlorpromazine hydrochloride can increase prolactin levels in rats. 7-Hydroxychlorpromazine hydrochloride can increase dopamine turnover and has a sedative effect. In addition, 7-Hydroxychlorpromazine hydrochloride can effectively inhibit amphetamine-induced stereotyped behavior in rats and is used in the study of psychosis .

HY-157075S

(Z)-Rilpivirine-d4
(Z)-Rilpivirine-d₄ (R278474-d₄; TMC278-d₄; DB08864-d₄) is deuterium-labeled (Z)-Rilpivirine .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16658BG

Z-VAD-FMK	Caspase Apoptosis	Cancer
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

HY-13259G

MG-132 Z-Leu-Leu-Leu-al	Proteasome Autophagy Apoptosis	Cancer
MG-132 (GMP) (Z-Leu-Leu-Leu-al (GMP)) is MG-132 (HY-13259) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC₅₀s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis .

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