2. Apoptosis
  3. Caspase
  4. Z-DEVD-AMC

Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. AMC can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Z-DEVD-AMC Chemical Structure

Z-DEVD-AMC Chemical Structure

Size Price Stock Quantity
1 mg USD 66 In-stock
5 mg USD 165 In-stock
10 mg USD 260 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Z-DEVD-AMC Related Antibodies

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. AMC can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates[1].

Molecular Weight

767.74

Formula

C36H41N5O14
Appearance

Solid

Color

White to off-white

Emission (Em)

480
Excitation (Ex)

390
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (43.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3025 mL 6.5126 mL 13.0252 mL
5 mM 0.2605 mL 1.3025 mL 2.6050 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3025 mL 6.5126 mL 13.0252 mL 32.5631 mL
5 mM 0.2605 mL 1.3025 mL 2.6050 mL 6.5126 mL
10 mM 0.1303 mL 0.6513 mL 1.3025 mL 3.2563 mL
15 mM 0.0868 mL 0.4342 mL 0.8683 mL 2.1709 mL
20 mM 0.0651 mL 0.3256 mL 0.6513 mL 1.6282 mL
25 mM 0.0521 mL 0.2605 mL 0.5210 mL 1.3025 mL
30 mM 0.0434 mL 0.2171 mL 0.4342 mL 1.0854 mL
40 mM 0.0326 mL 0.1628 mL 0.3256 mL 0.8141 mL
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Z-DEVD-AMC Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z-DEVD-AMCCaspasecaspase-3 substratefluorescence spectrometryAMCInhibitorinhibitorinhibit

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