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  5. IL-33 Protein, Cynomolgus (HEK293, His)

IL-33 Protein, Cynomolgus (HEK293, His)

Cat. No.: HY-P77966
Handling Instructions

IL-33 Protein, part of the IL-1 family, is a divergent cytokine pivotal in immune responses and inflammation. Operating through its receptor ST2, IL-33 promotes activation and recruitment of immune cells like Th2 cells, mast cells, and eosinophils to inflammation sites. Produced by epithelial and endothelial cells, IL-33 induces pro-inflammatory cytokines and chemokines. Implicated in asthma, allergic diseases, and autoimmune disorders, IL-33 emerges as a therapeutic target for immune response modulation. IL-33 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-33 protein, expressed by HEK293, with N-His labeled tag. The total length of IL-33 Protein, Cynomolgus (HEK293, His) is 162 a.a., with molecular weight of 25-30 kDa.

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Description

IL-33 Protein, part of the IL-1 family, is a divergent cytokine pivotal in immune responses and inflammation. Operating through its receptor ST2, IL-33 promotes activation and recruitment of immune cells like Th2 cells, mast cells, and eosinophils to inflammation sites. Produced by epithelial and endothelial cells, IL-33 induces pro-inflammatory cytokines and chemokines. Implicated in asthma, allergic diseases, and autoimmune disorders, IL-33 emerges as a therapeutic target for immune response modulation. IL-33 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-33 protein, expressed by HEK293, with N-His labeled tag. The total length of IL-33 Protein, Cynomolgus (HEK293, His) is 162 a.a., with molecular weight of 25-30 kDa.

Background

IL-33 protein belongs to the IL-1 family and is known for its high divergence from other family members. It functions as an important cytokine involved in various immune responses and inflammatory processes. IL-33 plays a crucial role in promoting the activation and recruitment of immune cells, such as T-helper 2 (Th2) cells, mast cells, and eosinophils, to sites of inflammation. It is primarily produced by epithelial and endothelial cells and acts through its receptor, ST2, to induce the production of other pro-inflammatory cytokines and chemokines. IL-33 has been implicated in various diseases, including asthma, allergic diseases, and autoimmune disorders, highlighting its significance as a therapeutic target for modulating immune responses.

Species

Cynomolgus

Source

HEK293

Tag

N-His

Accession

A0A2K5W3I1 (H109-I270)

Gene ID

102140695  [NCBI]

Molecular Construction
N-term
His
IL-33 (H109-I270)
Accession # A0A2K5W3I1
C-term
Synonyms
C9orf26 Z; DVS27; IL1F11; NF-HEV; NFEHEV; IL33; DV27; C9ORF26; RP11-575C20.2
Molecular Weight

25-30 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

IL-33 Protein, Cynomolgus (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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IL-33 Protein, Cynomolgus (HEK293, His)
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