1. Anti-infection
  2. Bacterial
  3. TH-Z93

TH-Z93, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 90 nM).

For research use only. We do not sell to patients.

TH-Z93 Chemical Structure

TH-Z93 Chemical Structure

CAS No. : 2260887-09-8

Size Price Stock Quantity
1 mg USD 150 In-stock
5 mg USD 380 In-stock
10 mg USD 550 In-stock
25 mg USD 850 In-stock
50 mg USD 1150 In-stock
100 mg USD 1550 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TH-Z93, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 90 nM)[1].

IC50 & Target

FPPS[1]

In Vivo

TH-Z93 (20 μg, i.p.) exhibits strong prophylactic effects in a pathogenic influenza model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16-OVA cells (s.c.) xenograft mice model[1].
Dosage: 20 μg
Administration: Intraperitoneal injection (i.p.)
Result: Inhibited tumor growth and prolonged survival.
Molecular Weight

368.26

Formula

C12H22N2O7P2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(C(P(O)(O)=O)NC1=NC=CC(OCCCCCC)=C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 1.89 mg/mL (5.13 mM; ultrasonic and warming and adjust pH to 10 with NaOH and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7155 mL 13.5774 mL 27.1547 mL
5 mM 0.5431 mL 2.7155 mL 5.4309 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.7155 mL 13.5774 mL 27.1547 mL 67.8868 mL
5 mM 0.5431 mL 2.7155 mL 5.4309 mL 13.5774 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

TH-Z93 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
TH-Z93
Cat. No.:
HY-150167
Quantity:
MCE Japan Authorized Agent: