TH-Z93
Based on 1 Customer Validation
TH-Z93, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 90 nM).
For research use only. We do not sell to patients.
- Purity: 98.41%
- CAS No.: 2260887-09-8
- Formula: C12H22N2O7P2
- Molecular Weight:368.26
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
FPPS[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:B16-OVA cells (s.c.) xenograft mice model[1].
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Dosage:20 μg
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Administration:Intraperitoneal injection (i.p.)
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Result:Inhibited tumor growth and prolonged survival.
Chemical Information
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CAS No. 2260887-09-8
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Appearance Solid
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Molecular Weight 368.26
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Formula C12H22N2O7P2
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Color White to off-white
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SMILES
O=P(O)(C(P(O)(O)=O)NC1=NC=CC(OCCCCCC)=C1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 7.81 mg/mL (21.21 mM; ultrasonic and warming and adjust pH to 9 with NaOH and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.7155 mL | 13.5774 mL | 27.1547 mL | 67.8868 mL |
| 5 mM | 0.5431 mL | 2.7155 mL | 5.4309 mL | 13.5774 mL | |
| 10 mM | 0.2715 mL | 1.3577 mL | 2.7155 mL | 6.7887 mL | |
| 15 mM | 0.1810 mL | 0.9052 mL | 1.8103 mL | 4.5258 mL | |
| 20 mM | 0.1358 mL | 0.6789 mL | 1.3577 mL | 3.3943 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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