2. Protein Tyrosine Kinase/RTK Apoptosis
  3. FLT3 Apoptosis
  4. (Z)-SU5614

(Z)-SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3.

For research use only. We do not sell to patients.

(Z)-SU5614 Chemical Structure

(Z)-SU5614 Chemical Structure

CAS No. : 1055412-47-9

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 99 In-stock
Solution
10 mM * 1 mL in DMSO USD 99 In-stock
Solid
1 mg USD 33 In-stock
5 mg USD 70 In-stock
10 mg USD 90 In-stock
25 mg USD 190 In-stock
50 mg USD 330 In-stock
100 mg USD 590 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

(Z)-SU5614 Related Antibodies

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Description

(Z)-SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3[1].

Molecular Weight

272.73

Formula

C15H13ClN2O
CAS No.
Appearance

Solid

Color

Brown to black

SMILES

O=C1NC2=C(C=C(Cl)C=C2)/C1=C/C3=C(C)C=C(C)N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (61.12 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6666 mL 18.3331 mL 36.6663 mL
5 mM 0.7333 mL 3.6666 mL 7.3333 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6666 mL 18.3331 mL 36.6663 mL 91.6657 mL
5 mM 0.7333 mL 3.6666 mL 7.3333 mL 18.3331 mL
10 mM 0.3667 mL 1.8333 mL 3.6666 mL 9.1666 mL
15 mM 0.2444 mL 1.2222 mL 2.4444 mL 6.1110 mL
20 mM 0.1833 mL 0.9167 mL 1.8333 mL 4.5833 mL
25 mM 0.1467 mL 0.7333 mL 1.4667 mL 3.6666 mL
30 mM 0.1222 mL 0.6111 mL 1.2222 mL 3.0555 mL
40 mM 0.0917 mL 0.4583 mL 0.9167 mL 2.2916 mL
50 mM 0.0733 mL 0.3667 mL 0.7333 mL 1.8333 mL
60 mM 0.0611 mL 0.3056 mL 0.6111 mL 1.5278 mL
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(Z)-SU5614 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Z)-SU56141055412-47-9FLT3ApoptosisCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Inhibitorinhibitorinhibit

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