(Z)-SU5614
Based on 1 Customer Validation
(Z)-SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3.
For research use only. We do not sell to patients.
- Purity: 98.09%
- CAS No.: 1055412-47-9
- Formula: C15H13ClN2O
- Molecular Weight:272.73
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Apoptosis Compound Library
HY-L003
-
Kinase Inhibitor Library
HY-L009
-
Protein Tyrosine Kinase Compound Library
HY-L016
-
Anti-Cancer Compound Library
HY-L025
-
Covalent Screening Library
HY-L036
-
Anti-Blood Cancer Compound Library
HY-L079
-
Membrane Protein-targeted Compound Library
HY-L149
-
Highly Selective Inhibitors Library
HY-L158
-
Highly Selective Activators Library
HY-L159
-
Cytokine Inhibitors Library
HY-L161
-
Cell Death Library
HY-L162
-
Anti-Hematopathy Compound Library
HY-L171
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Covalent Screening Library Plus
HY-L036P
-
Bioactive Compound Library
HY-L001
-
Anti-Brain Cancer Compound Library
HY-L188
-
Protein Kinase Compound Library
HY-L196
-
Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
-
High-Throughput Bioactive Compound Library
HY-L205
-
Posttranslational Modification Library
HY-L226
-
MCE Kinase Hinge Binder Fragment Library
HY-L907
-
Covalent Fragment Library
HY-L909
-
Multifunctional Covalent Fragment Library
HY-L916
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
1 μM
Compound: SU-5614
|
Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cells
Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cells
|
[PMID: 20117004] |
Chemical Information
-
CAS No. 1055412-47-9
-
Appearance Solid
-
Molecular Weight 272.73
-
Formula C15H13ClN2O
-
Color Brown to black
-
SMILES
O=C1NC2=C(C=C(Cl)C=C2)/C1=C/C3=C(C)C=C(C)N3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 13.89 mg/mL (50.93 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (270 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6666 mL | 18.3331 mL | 36.6663 mL | 91.6657 mL |
| 5 mM | 0.7333 mL | 3.6666 mL | 7.3333 mL | 18.3331 mL | |
| 10 mM | 0.3667 mL | 1.8333 mL | 3.6666 mL | 9.1666 mL | |
| 15 mM | 0.2444 mL | 1.2222 mL | 2.4444 mL | 6.1110 mL | |
| 20 mM | 0.1833 mL | 0.9167 mL | 1.8333 mL | 4.5833 mL | |
| 25 mM | 0.1467 mL | 0.7333 mL | 1.4667 mL | 3.6666 mL | |
| 30 mM | 0.1222 mL | 0.6111 mL | 1.2222 mL | 3.0555 mL | |
| 40 mM | 0.0917 mL | 0.4583 mL | 0.9167 mL | 2.2916 mL | |
| 50 mM | 0.0733 mL | 0.3667 mL | 0.7333 mL | 1.8333 mL |
Powered by Bioz