PD-1/PD-L1-IN-43
PD-1/PD-L1-IN-43 (compound Z13) is a small-molecule inhibitors targeting the PD-1/PD-L1 interaction. PD-1/PD-L1-IN-43 exhibites potent in vivo antitumor efficacy against B16-F10 melanoma. PD-1/PD-L1-IN-43 inhibits tumor growth by blocking the interaction between PD-1 and PD-L1. PD-1/PD-L1-IN-43 can be used in anti-tumor studies.
For research use only. We do not sell to patients.
- Formula: C27H25N3O4
- Molecular Weight:455.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
PD-1/PD-L1-IN-43 (0 - 20 μM; 48 h) can reactivate immunosuppressed Jurkat T cells to kill HepG2 cells in the cell co-culture system[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2/Jurkat co-culture cell model
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Concentration:0 - 20 μM
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Incubation Time:48 h
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Result:Reduced the survival rate of HepG2 cells to 55.16% compared to the control group.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:mouse model of B16-F10 melanoma
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Dosage:20 and 40 mg/kg
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Administration:Intraperitoneal injection (i.p.)
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Result:The tumor growth inhibition values (TGI) of the treatment groups were 42.4 % and 52.6 % at doses of 20 and 40 mg/kg.
Chemical Information
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Molecular Weight 455.51
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Formula C27H25N3O4
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SMILES
O=C(N1N=CC2=C1C=CC=C2C3=CC=C4OCCOC4=C3)C5=CC=C(C=C5)CN6CC[C@H](C6)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)